ArticlePeerJ2016
Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Low expression of aging-related NRXN3 is associated with Alzheimer disease: A systematic review and meta-analysis.Medicine · 2018Pooled it
- Bibliometric analysis and core target identification of network pharmacology on neuroinflammation in central nervous system disorders: Trends, collaborations, and future directions.Neuroprotection (Chichester, England) · 2025Review
- Chuanxiong Rhizoma regulates ferroptosis and the immune microenvironment in ischemic stroke through the JAK-STAT3 pathway.Scientific reports · 2024Article
- Integrative multi-omics approach using random forest and artificial neural network models for early diagnosis and immune infiltration characterization in ischemic stroke.Frontiers in neurology · 2024Article
- Screening of potentially active compounds against rheumatoid arthritis in the Juan-Bi decoction using systems pharmacology and animal experiments.Frontiers in cell and developmental biology · 2024Article
- Observational
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- Prediction of Mechanosensitive Genes in Vascular Endothelial Cells Under High Wall Shear Stress.Frontiers in genetics · 2021Article
- Genetic Variation of Inflammatory Genes to Ischemic Stroke Risk in a Chinese Han Population.Pharmacogenomics and personalized medicine · 2021Article
- Article
- Article
- Sex Difference of Ribosome in Stroke-Induced Peripheral Immunosuppression by Integrated Bioinformatics Analysis.BioMed research international · 2020Article
- Article
- Differential Impact of Risk Factors on Stroke Occurrence Among Men Versus Women in West Africa.Stroke · 2019Article
- Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma.American journal of translational research · 2019Article
- Integrated analysis of 10 lymphoma datasets identifies E2F8 as a key regulator in Burkitt's lymphoma and mantle cell lymphoma.American journal of translational research · 2019Article
- Comprehensive integrated analysis of gene expression datasets identifies key anti-cancer targets in different stages of breast cancer.Experimental and therapeutic medicine · 2018Article
- Integrative machine learning analysis of multiple gene expression profiles in cervical cancer.PeerJ · 2018Article
- Interleukin-6 (IL-6) rs1800796 and cyclin dependent kinase inhibitor (CDKN2A/CDKN2B) rs2383207 are associated with ischemic stroke in indigenous West African Men.Journal of the neurological sciences · 2017Article
- Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets.Oncotarget · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemic stroke is a common neurological disorder and the burden in the world is growing. This study aims to explore the effect of sex and age difference on ischemic stroke using integrated microarray datasets. The results showed a dramatic difference in whole gene expression profiles and influenced pathways between males and females, and also in the old and young individuals. Furthermore, compared with old males, old female patients showed more serious biological function damage. However, females showed less affected pathways than males in young subjects. Functional interaction networks showed these differential expression genes were mostly related to immune and inflammation-related functions. In addition, we found ARG1 and MMP9 were up-regulated in total and all subgroups. Importantly, IL1A, ILAB, IL6 and TNF and other anti-stroke target genes were up-regulated in males. However, these anti-stroke target genes showed low expression in females. This study found huge sex and age differences in ischemic stroke especially the opposite expression of anti-stroke target genes. Future studies are needed to uncover these pathological mechanisms, and to take appropriate pre-prevention, treatment and rehabilitation measures.
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Registered trials
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