Evidence map›Paper›PMID 27672504›Full record

ArticlePeerJ2016

Muscle size explains low passive skeletal muscle force in heart failure patients.

Fausto Antonio Panizzolo, Andrew J Maiorana, Louise H Naylor, Lawrence G Dembo, David G Lloyd, Daniel J Green, Jonas Rubenson

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Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Fausto Antonio PanizzoloJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, United States; The School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, WA, Australia.
Andrew J MaioranaAdvanced Heart Failure and Cardiac Transplant Service, Royal Perth Hospital, Perth, WA, Australia; School of Physiotherapy and Exercise Science, Curtin University, Perth, WA, Australia.
Louise H NaylorThe School of Sport Science, Exercise and Health, The University of Western Australia , Crawley , WA , Australia.
Lawrence G DemboEnvision Medical Imaging , Perth , WA , Australia.
David G LloydCentre for Musculoskeletal Research, Griffith Health Institute, Griffith University , Gold Coast , QLD , Australia.
Daniel J GreenThe School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, WA, Australia; Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom.
Jonas RubensonThe School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, WA, Australia; Biomechanics Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, PA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlterations in skeletal muscle function and architecture have been linked to the compromised exercise capacity characterizing chronic heart failure (CHF). However, how passive skeletal muscle force is affected in CHF is not clear. Understanding passive force characteristics in CHF can help further elucidate the extent to which altered contractile properties and/or architecture might affect muscle and locomotor function. Therefore, the aim of this study was to investigate passive force in a single muscle for which non-invasive measures of muscle size and estimates of fiber force are possible, the soleus (SOL), both in CHF patients and age- and physical activity-matched control participants.

methodsPassive SOL muscle force and size were obtained by means of a novel approach combining experimental data (dynamometry, electromyography, ultrasound imaging) with a musculoskeletal model.

resultsWe found reduced passive SOL forces (∼30%) (at the same relative levels of muscle stretch) in CHF vs. healthy individuals. This difference was eliminated when force was normalized by physiological cross sectional area, indicating that reduced force output may be most strongly associated with muscle size. Nevertheless, passive force was significantly higher in CHF at a given absolute muscle length (non length-normalized) and likely explained by the shorter muscle slack lengths and optimal muscle lengths measured in CHF compared to the control participants. This later factor may lead to altered performance of the SOL in functional tasks such gait. DISCUSSION: These findings suggest introducing exercise rehabilitation targeting muscle hypertrophy and, specifically for the calf muscles, exercise that promotes muscle lengthening.

Indexed as

Heart failurePassive forceSkeletal muscleSoleusUltrasound

Identifiers

PMID27672504
PMCPMC5028761

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.