ArticlePatient related outcome measures2016
Patient-reported symptom distress, and most bothersome issues, before and during cancer treatment.
Article in Patient related outcome measures, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Fatigue severity and avoidance among individuals with chronic disease: A meta-analysis.Journal of psychosomatic research · 2022Pooled it
- Hypnosis for Symptom Control in Cancer Patients at the End-of-Life: A Systematic Review.The International journal of clinical and experimental hypnosisPooled it
- A mixed-methods study of how cancer-related fatigue affects occupational participation and engagement, and is managed in daily life.The British journal of occupational therapy · 2026Article
- Cancer survivors' acceptability and perspectives on engagement with digital cognitive-behavioral therapy for insomnia: a mixed methods perspective.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Age-related differences in the occurrence, severity, and distress of symptoms in older patients at the initiation of chemotherapy.BMC geriatrics · 2023Article
- When can cancer patient treatment nonadherence be considered intentional or unintentional? A scoping review.PloS one · 2023Article
- Involving patients in the process: Development of a constipation patient-reported outcome measure for symptoms and quality of life.Computational and structural biotechnology journal · 2023Article
- Building family caregiver skills using a simulation-based intervention for care of patients with cancer: protocol for a randomized controlled trial.BMC nursing · 2021Article
- The Cancer Rehabilitation Medicine Metrics Consortium: A Path to Enhanced, Multi-Site Outcome Assessment to Enhance Care and Demonstrate Value.Frontiers in oncology · 2020Article
- Screening for clinical insomnia in cancer patients with the Edmonton Symptom Assessment System-Revised: a specific sleep item is needed.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
introductionFrequently reported symptoms and treatment side effects may not be the most bothersome issues to patients with cancer. The purpose of this study was to investigate patient-reported symptom distress and bothersome issues among participants with cancer.
methodsParticipants completed the Symptom Distress Scale-15 before treatment (T1) and during cancer treatment (T2) and reported up to two most bothersome issues among symptoms rated with moderate-to-severe distress. We compared symptom ratings and perceived bother and explored two approaches predicting patients' most bothersome issues: worst absolute symptom score or worst change from pretreatment.
resultsSignificantly, (P≤0.0002) more patients reported moderate-to-severe distress at T2 for eight of 13 symptoms. At T1, 81% of patients reported one and 56% reported multiple symptoms with moderate-to-severe distress, while at T2, 89% reported one and 69% reported multiple symptoms with moderate-to-severe distress. Impact on sexual activity/interest, pain, fatigue, and insomnia were the most prevalent symptoms with moderate-to-severe distress. Fatigue, pain, and insomnia were perceived most often as bothersome. When one symptom was rated moderate-to-severe, predictive accuracy of the absolute score was 46% and 48% (T1 & T2) and 38% with the change score (T2-T1). When two or more symptoms were rated moderate-to-severe, predictive accuracy of the absolute score was 76% and 79% (T1 & T2) and 70% with the change score (T2-T1).
conclusionMore patients experienced moderate-to-severe symptom distress after treatment initiation. Patient identification of bothersome issues could not be assumed based on prevalence of symptoms reported with moderate-to-severe distress. The absolute symptom distress scores identified patients' most bothersome issues with good accuracy, outperforming change scores.
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