Evidence map›Paper›PMID 27672271›Full record

ReviewWorld journal of gastroenterology2016

Aberrant regulation of Wnt signaling in hepatocellular carcinoma.

Li-Juan Liu, Shui-Xiang Xie, Ya-Tang Chen, Jing-Ling Xue, Chuan-Jie Zhang, Fan Zhu

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 101 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Li-Juan LiuLi-Juan Liu, Ya-Tang Chen, Fan Zhu, Department of Medical Microbiology, School of Medicine, Wuhan University, Wuhan 430071, Hubei Province, China.
Shui-Xiang XieLi-Juan Liu, Ya-Tang Chen, Fan Zhu, Department of Medical Microbiology, School of Medicine, Wuhan University, Wuhan 430071, Hubei Province, China.
Ya-Tang ChenLi-Juan Liu, Ya-Tang Chen, Fan Zhu, Department of Medical Microbiology, School of Medicine, Wuhan University, Wuhan 430071, Hubei Province, China.
Jing-Ling XueLi-Juan Liu, Ya-Tang Chen, Fan Zhu, Department of Medical Microbiology, School of Medicine, Wuhan University, Wuhan 430071, Hubei Province, China.
Chuan-Jie ZhangLi-Juan Liu, Ya-Tang Chen, Fan Zhu, Department of Medical Microbiology, School of Medicine, Wuhan University, Wuhan 430071, Hubei Province, China.
Fan ZhuLi-Juan Liu, Ya-Tang Chen, Fan Zhu, Department of Medical Microbiology, School of Medicine, Wuhan University, Wuhan 430071, Hubei Province, China.
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies in the world. Several signaling pathways, including the wingless/int-1 (Wnt) signaling pathway, have been shown to be commonly activated in HCC. The Wnt signaling pathway can be triggered via both catenin β1 (CTNNB1)-dependent (also known as "canonical") and CTNNB1-independent (often referred to as "non-canonical") pathways. Specifically, the canonical Wnt pathway is one of those most frequently reported in HCC. Aberrant regulation from three complexes (the cell-surface receptor complex, the cytoplasmic destruction complex and the nuclear CTNNB1/T-cell-specific transcription factor/lymphoid enhancer binding factor transcriptional complex) are all involved in HCC. Although the non-canonical Wnt pathway is rarely reported, two main non-canonical pathways, Wnt/planar cell polarity pathway and Wnt/Ca(2+) pathway, participate in the regulation of hepatocarcinogenesis. Interestingly, the canonical Wnt pathway is antagonized by non-canonical Wnt signaling in HCC. Moreover, other signaling cascades have also been demonstrated to regulate the Wnt pathway through crosstalk in HCC pathogenesis. This review provides a perspective on the emerging evidence that the aberrant regulation of Wnt signaling is a critical mechanism for the development of HCC. Furthermore, crosstalk between different signaling pathways might be conducive to the development of novel molecular targets of HCC.

Indexed as

Gene Expression Regulation, NeoplasticWnt Signaling PathwayAnimalsbeta CateninBiomarkers, TumorCarcinoma, HepatocellularCell ProliferationCytoplasmHepatitis BHepatitis B virusHumansLiver NeoplasmsSignal TransductionWnt1 ProteinXenopusbeta CateninBiomarkers, TumorCTNNB1 protein, humanWnt1 ProteinWNT1 protein, humanCanonical wingless/int-1 signalingCatenin β1CrosstalkHepatocellular carcinomaNon-canonical wingless/int-1 signalingWingless/int-1

Identifiers

PMID27672271
PMCPMC5011664
OpenAlexW2422294114

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.