ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
Convergent evolution of pathogenicity islands in helper cos phage interference.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Capsid redirection mechanism of thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Bridging Classical Methodologies inMicroorganisms · 2024Review
- A phage satellite manipulates the viral DNA packaging motor to inhibit phage and promote satellite spread.Nucleic acids research · 2024Article
- A phage satellite manipulates the viral DNA packaging motor to inhibit phage and promote satellite spread.bioRxiv : the preprint server for biology · 2024Article
- AeLife · 2024Article
- AbioRxiv : the preprint server for biology · 2023Article
- A phage parasite deploys a nicking nuclease effector to inhibit viral host replication.Nucleic acids research · 2022Article
- Mobilization of vitamin BCell reports · 2021Article
- Phage satellites and their emerging applications in biotechnology.FEMS microbiology reviews · 2021Review
- Shape shifter: redirection of prolate phage capsid assembly by staphylococcal pathogenicity islands.Nature communications · 2021Article
- Bacteriophage Technology and Modern Medicine.Antibiotics (Basel, Switzerland) · 2021Review
- Molecular Piracy: Redirection of Bacteriophage Capsid Assembly by Mobile Genetic Elements.Viruses · 2019Review
- Hijacking the Hijackers: Escherichia coli Pathogenicity Islands Redirect Helper Phage Packaging for Their Own Benefit.Molecular cell · 2019Article
- Pathogenicity Islands and Their Role in Staphylococcal Biology.Microbiology spectrum · 2019Review
- Article
- Mobilisation Mechanism of Pathogenicity Islands by Endogenous Phages in Staphylococcus aureus clinical strains.Scientific reports · 2018Article
- Phage-inducible chromosomal islands are ubiquitous within the bacterial universe.The ISME journal · 2018Article
- Article
- Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer.eLife · 2017Article
- Staphylococcal pathogenicity islands-movers and shakers in the genomic firmament.Current opinion in microbiology · 2017Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Staphylococcus aureus pathogenicity islands (SaPIs) are phage satellites that exploit the life cycle of their helper phages for their own benefit. Most SaPIs are packaged by their helper phages using a headful (pac) packaging mechanism. These SaPIs interfere with pac phage reproduction through a variety of strategies, including the redirection of phage capsid assembly to form small capsids, a process that depends on the expression of the SaPI-encoded cpmA and cpmB genes. Another SaPI subfamily is induced and packaged by cos-type phages, and although these cos SaPIs also block the life cycle of their inducing phages, the basis for this mechanism of interference remains to be deciphered. Here we have identified and characterized one mechanism by which the SaPIs interfere with cos phage reproduction. This mechanism depends on a SaPI-encoded gene, ccm, which encodes a protein involved in the production of small isometric capsids, compared with the prolate helper phage capsids. As the Ccm and CpmAB proteins are completely unrelated in sequence, this strategy represents a fascinating example of convergent evolution. Moreover, this result also indicates that the production of SaPI-sized particles is a widespread strategy of phage interference conserved during SaPI evolution.This article is part of the themed issue 'The new bacteriology'.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.