Evidence map›Paper›PMID 27672151›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016

From homeostasis to pathology: decrypting microbe-host symbiotic signals in the intestinal crypt.

Thierry Pédron, Giulia Nigro, Philippe J Sansonetti

Open access · bronzeAbstract readReview
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Intravital imaging of translocated bacteria via fluorogenic labeling of gut microbiota in situ.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. The gut microbiota and its biogeography.Nature reviews. Microbiology · 2024
    Review
  3. Microbiology and molecular biology reviews : MMBR · 2021
    Review
  4. Article
  5. Review
  6. Article
  7. The germ-organ theory of non-communicable diseases.Nature reviews. Microbiology · 2018
    Review
  8. Infection and immunity · 2017
    Article
  9. The new bacteriology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Thierry PédronUnité de Pathogénie Microbienne Moléculaire, Institut Pasteur, 28 Rue du Dr Roux, 75724 Paris cédex 15, France Unité INSERM 1202, Institut Pasteur, Paris, France.
Giulia NigroUnité de Pathogénie Microbienne Moléculaire, Institut Pasteur, 28 Rue du Dr Roux, 75724 Paris cédex 15, France Unité INSERM 1202, Institut Pasteur, Paris, France.
Philippe J SansonettiUnité de Pathogénie Microbienne Moléculaire, Institut Pasteur, 28 Rue du Dr Roux, 75724 Paris cédex 15, France Unité INSERM 1202, Institut Pasteur, Paris, France Chaire de Microbiologie et Maladies Infectieuses, Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France philippe.sansonetti@pasteur.fr.ORCID 0000-0001-7542-4527
Inserm · FR

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Metagenomic analysis of the human intestinal microbiome has provided a wealth of information that allowed an exceptionally detailed description of its microbial content and physiological potential. It also set the basis for studies allowing correlation of alterations in the balance of this microbiota and the occurrence of a certain number of emerging diseases, such as inflammatory bowel diseases, obesity and diabetes, and possibly colorectal cancer. The time has come to give the intestinal microbiota in symbiosis with its host an experimental dimension. This brief review summarizes our attempt at developing a cellular microbiology of the mutualistic symbiosis established between the gut microbiota and the host intestinal surface. Particular attention is paid to the intestinal crypt, due to its role in epithelial regeneration.This article is part of the themed issue 'The new bacteriology'.

Indexed as

SymbiosisGastrointestinal MicrobiomeHomeostasisHumansIntestinesgut microbiotaintestinal cryptspathobiont

Identifiers

PMID27672151
PMCPMC5052744
OpenAlexW2525545859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.