Evidence map›Paper›PMID 27672100›Full record

ArticleJournal of radiation research2017

DNA damage response induces structural alterations in histone H3-H4.

Yudai Izumi, Kentaro Fujii, Satoshi Yamamoto, Koichi Matsuo, Hirofumi Namatame, Masaki Taniguchi, Akinari Yokoya

Open access · goldAbstract read
In one paragraph

Article in Journal of radiation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yudai IzumiHiroshima Synchrotron Radiation Center, Hiroshima University, 2-313 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan izumi-yudai@hiroshima-u.ac.jp.
Kentaro FujiiNational Institutes for Quantum and Radiological Science and Technology (QST) 2-4, Ooaza-Shirakata, Tokai, Naka, Ibaraki 319-1106, Japan.
Satoshi YamamotoGraduate School of Science and Engineering, Ibaraki University, 2-1-1, Bunkyo, Mito, Ibaraki 310-0056, Japan.
Koichi MatsuoHiroshima Synchrotron Radiation Center, Hiroshima University, 2-313 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan.
Hirofumi NamatameHiroshima Synchrotron Radiation Center, Hiroshima University, 2-313 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan.
Masaki TaniguchiHiroshima Synchrotron Radiation Center, Hiroshima University, 2-313 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan.
Akinari YokoyaNational Institutes for Quantum and Radiological Science and Technology (QST) 2-4, Ooaza-Shirakata, Tokai, Naka, Ibaraki 319-1106, Japan.
Hiroshima University · JPNational Institutes for Quantum and Radiological Science and Technology · JPIbaraki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of α-helix and an increment of β-strand contents of histone H3-H4 extracted from X-ray-irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our previously reported results for histone H2A-H2B. These results strongly suggest that histones share roles in DNA damage responses, particularly in DNA repair processes and chromatin remodeling, via a specific structural alteration of each histone.

Indexed as

DNA DamageCell Line, TumorCircular DichroismDNA RepairElectrophoresis, Polyacrylamide GelHistonesHumansProtein Structure, SecondarySynchrotronsX-RaysHistoneschromatin remodelingcircular dichroismDNA repairhistone dynamicspost-translational modificationsynchrotron radiation

Identifiers

PMID27672100
PMCPMC5321191
OpenAlexW2526872567

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.