ArticleGenetics2016
Joint Prediction of the Effective Population Size and the Rate of Fixation of Deleterious Mutations.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Causal inference clarifies the roles of background selection and mutation rate variation in shaping human genetic diversity.bioRxiv : the preprint server for biology · 2026Article
- Background selection in recombining genomes and its consequences for the maintenance of variation in complex traits.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- ThebioRxiv : the preprint server for biology · 2026Article
- A model for background selection in non-equilibrium populations.bioRxiv : the preprint server for biology · 2025Article
- A model of Hill-Robertson interference caused by purifying selection in a nonrecombining genome.Genetics · 2025Article
- FST and genetic diversity in an island model with background selection.PLoS genetics · 2024Article
- Population Size in Evolutionary Biology Is More Than the Effective Size.Evolutionary applications · 2024Article
- Background Selection From Unlinked Sites Causes Nonindependent Evolution of Deleterious Mutations.Genome biology and evolution · 2024Article
- A quantitative genetic model of background selection in humans.PLoS genetics · 2024Article
- The estimates of effective population size based on linkage disequilibrium are virtually unaffected by natural selection.PLoS genetics · 2022Article
- Highly pleiotropic variants of human traits are enriched in genomic regions with strong background selection.Human genetics · 2021Article
- Article
- Background selection as null hypothesis in population genomics: insights and challenges fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
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Authors and funding
2 authors.
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Abstract
Mutation, genetic drift, and selection are considered the main factors shaping genetic variation in nature. There is a lack, however, of general predictions accounting for the mutual interrelation between these factors. In the context of the background selection model, we provide a set of equations for the joint prediction of the effective population size and the rate of fixation of deleterious mutations, which are applicable both to sexual and asexual species. For a population of N haploid individuals and a model of deleterious mutations with effect s appearing with rate U in a genome L Morgans long, the asymptotic effective population size (N
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