ArticleInfection and immunity2016
Treatment with Cestode Parasite Antigens Results in Recruitment of CCR2+ Myeloid Cells, the Adoptive Transfer of Which Ameliorates Colitis.
Article in Infection and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Hymenolepis nana antigens alleviate ulcerative colitis by promoting intestinal stem cell proliferation and differentiation via AhR/IL-22 signaling pathway.PLoS neglected tropical diseases · 2024Article
- Origin and Function of Monocytes in Inflammatory Bowel Disease.Journal of inflammation research · 2024Review
- The Roles of Various Immune Cell Populations in Immune Response against Helminths.International journal of molecular sciences · 2023Review
- The TapewormPathogens (Basel, Switzerland) · 2022Review
- Macrophage Gal/GalNAc lectin 2 (MGL2)Scientific reports · 2022Article
- The Neglected Gut Microbiome: Fungi, Protozoa, and Bacteriophages in Inflammatory Bowel Disease.Inflammatory bowel diseases · 2022Review
- Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect.Microorganisms · 2021Article
- Cellular and humoral peritoneal immunity to Mesocestoides vogae metacestode infection in mice.Parasites & vectors · 2021Article
- Article
- Characterization of Tapeworm Metabolites and Their Reported Biological Activities.Molecules (Basel, Switzerland) · 2019Article
- Role of mast cells in the generation of a T-helper type 2 dominated anti-helminthic immune response.Bioscience reports · 2019Article
- Management of Adverse Events in Cancer Patients Treated With PD-1/PD-L1 Blockade: Focus on Asian Populations.Frontiers in pharmacology · 2019Review
- Young mice expel the tapeworm Hymenolepis diminuta and are protected from colitis by triggering a memory response with worm antigen.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells.Frontiers in immunology · 2018Review
- Identification of immunogenic proteins of the cysticercoid of Hymenolepis diminuta.Parasites & vectors · 2017Article
- Therapeutic potential of helminths in autoimmune diseases: helminth-derived immune-regulators and immune balance.Parasitology research · 2017Review
- Helminths in the gastrointestinal tract as modulators of immunity and pathology.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- New Data on Human Macrophages Polarization byFrontiers in immunology · 2017Article
- Parasite-Derived Proteins for the Treatment of Allergies and Autoimmune Diseases.Frontiers in microbiology · 2017Review
- Microbial Anti-Inflammatory Molecule (MAM) fromFrontiers in microbiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Awareness of the immunological underpinnings of host-parasite interactions may reveal immune signaling pathways that could be used to treat inflammatory disease in humans. Previously we showed that infection with the rat tapeworm, Hymenolepis diminuta, used as a model helminth, or systemic delivery of worm antigen (HdAg) significantly reduced the severity of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice. Extending these analyses, intraperitoneal injection of HdAg dose-dependently suppressed dextran sodium sulfate (DSS)-induced colitis, and this was paralleled by reduced gamma interferon (IFN-γ), interleukin-17 (IL-17), and tumor necrosis factor alpha (TNF-α) production and increased IL-10 production from mitogen-activated splenocytes. Treatment with HdAg resulted in a CCR2-dependent recruitment of CDllb
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.