ReviewEnvironmental science and pollution research international2016
Environmental pollutants: genetic damage and epigenetic changes in male germ cells.
Review in Environmental science and pollution research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04012385 (An Intervention Model for the Prevention of Infertility in Healthy Young Men Living in Highly Polluted Areas), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Intervention Model for the Prevention of Infertility in Healthy Young Men Living in Highly Polluted Areas
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- A systematic review of evidence for maternal preconception exposure to outdoor air pollution on Children's health.Environmental pollution (Barking, Essex : 1987) · 2023Pooled it
- Does air pollution play a role in infertility?: a systematic review.Environmental health : a global access science source · 2017Pooled it
- Artemisinin alleviates cisplatin-induced damage in GC-1 spermatogonia through ER stress mechanisms.Heliyon · 2025Article
- Article
- A Comparative Analysis of Orexins in the Physio-Pathological Processes of the Male Genital Tract: New Challenges? A Review.Veterinary sciences · 2024Review
- Small noncoding RNAs and sperm nuclear basic proteins reflect the environmental impact on germ cells.Molecular medicine (Cambridge, Mass.) · 2024Article
- Editorial: Mammalian spermatogenesis: genetic and environmental factors.Frontiers in cell and developmental biology · 2024Article
- Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study.Environmental health : a global access science source · 2023Article
- Molecular Alterations and Severe Abnormalities in Spermatozoa of Young Men Living in the "Valley of Sacco River" (Latium, Italy): A Preliminary Study.International journal of environmental research and public health · 2022Article
- The Changing Climate and Pregnancy Health.Current environmental health reports · 2022Review
- Studying the mechanism of sperm DNA damage caused by folate deficiency.Journal of cellular and molecular medicine · 2022Article
- Reprotoxic Impact of Environment, Diet, and Behavior.International journal of environmental research and public health · 2022Review
- Air Pollution and COVID-19: A Possible Dangerous Synergy for Male Fertility.International journal of environmental research and public health · 2021Review
- Microplastics: A Threat for Male Fertility.International journal of environmental research and public health · 2021Review
- Impact of environmental toxin exposure on male fertility potential.Translational andrology and urology · 2020Review
- Review
- Molecular Alterations in Spermatozoa of a Family Case Living in the Land of Fires. A First Look at Possible Transgenerational Effects of Pollutants.International journal of molecular sciences · 2020Article
- Discovery of the Involvement in DNA Oxidative Damage of Human Sperm Nuclear Basic Proteins of Healthy Young Men Living in Polluted Areas.International journal of molecular sciences · 2020Article
- Birth Cohorts in Highly Contaminated Sites: A Tool for Monitoring the Relationships Between Environmental Pollutants and Children's Health.Frontiers in public health · 2020Article
- Should Perturbation of the Preconceptive Environment be Considered a Risk Factor for the Development of Cardiovascular Disease Later in Life?Journal of the American Heart Association · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
About a quarter of the human diseases occurs for exposure to air pollution. The male reproductive system, and especially spermatogenesis, seems to be particularly sensitive. As result, male infertility is increasing in industrial countries becoming a top priority for public health. In addition to psychological distress and economic constraints, poorer semen quality may have trans-generational effects including congenital malformations in the offspring and predispose to later onset adult diseases. Genetic and epigenetic alterations are involved in the failure of spermatogenesis. In this paper, we reviewed the major evidences of the effects of air pollutants on male infertility as well as the role of sperm DNA damage and epigenetic changes in affecting spermatogenesis. A better knowledge on the effects of air contaminants on the molecular mechanisms leading to infertility is of huge importance to help clinicians in identifying the cause of infertility but above all, in defining preventive and therapeutic protocols.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.