Evidence map›Paper›PMID 27672039›Full record

ArticleNucleic acids research2017

Concerted effects of heterogeneous nuclear ribonucleoprotein C1/C2 to control vitamin D-directed gene transcription and RNA splicing in human bone cells.

Rui Zhou, Juw Won Park, Rene F Chun, Thomas S Lisse, Alejandro J Garcia, Kathryn Zavala, Jessica L Sea, Zhi-Xiang Lu, Jianzhong Xu, John S Adams and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The impact of vitamin D on cancer: A mini review.The Journal of steroid biochemistry and molecular biology · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. HnRNPL inhibits the osteogenic differentiation of PDLCs stimulated by SrClJournal of cellular and molecular medicine · 2019
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Rui ZhouUCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, Orthopedic Hospital, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Juw Won ParkMicrobiology, Immunology and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Rene F ChunUCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, Orthopedic Hospital, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Thomas S LisseThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Alejandro J GarciaUCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, Orthopedic Hospital, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Kathryn ZavalaUCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, Orthopedic Hospital, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Jessica L SeaUCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, Orthopedic Hospital, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Zhi-Xiang LuMicrobiology, Immunology and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Jianzhong XuDepartment of Orthopaedics, the Orthopedic Surgery Center of Chinese PLA, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
John S AdamsUCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, Orthopedic Hospital, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Yi XingMicrobiology, Immunology and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA yxing@ucla.edu.
Martin HewisonUCLA Orthopaedic Hospital, Department of Orthopaedic Surgery, Orthopedic Hospital, University of California at Los Angeles, Los Angeles, CA 90095, USA m.hewison@bham.ac.uk.ORCID 0000-0001-5806-9690
University of California, Los Angeles · USArmy Medical University · CNJackson Laboratory · US

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
NIGMS NIH HHS T32 GM007185
6 · The paper itself

Abstract

Traditionally recognized as an RNA splicing regulator, heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNPC1/C2) can also bind to double-stranded DNA and function in trans as a vitamin D response element (VDRE)-binding protein. As such, hnRNPC1/C2 may couple transcription induced by the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)

Indexed as

RNA SplicingTranscription, GeneticAlternative SplicingCell Line, TumorCluster AnalysisGene Expression ProfilingGene Expression RegulationGene Knockdown TechniquesHeterogeneous-Nuclear Ribonucleoprotein Group CHigh-Throughput Nucleotide SequencingHumansOsteocytesPromoter Regions, GeneticProtein BindingRNA InterferenceRNA PrecursorsHeterogeneous-Nuclear Ribonucleoprotein Group CRNA PrecursorsVitamin DVitamin D3 24-Hydroxylase

Identifiers

PMID27672039
PMCPMC5314791
OpenAlexW2526995709

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.