Trial reportHypertension (Dallas, Tex. : 1979)2016
The Role of the Autonomic Nervous System in the Regulation of Aortic Stiffness.
Trial report in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- Impact of supra-maximal interval training vs. high-intensity interval training on cardiac auto-regulation response in physically active adults.European journal of applied physiology · 2024Trial
- Acute psychological stress, autonomic function, and arterial stiffness among women.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020Trial
- Arterial stiffness in the context of heart rate and vasomotion during orthostatic stress and cognitive load.Frontiers in network physiology · 2026Article
- Association between cardiovascular, psychotropic and anti-inflammatory/analgesic drug use and vascular dysfunction in individuals with long COVID. BioICOPER study.Frontiers in cardiovascular medicine · 2025Article
- Acute cardiovascular responses to the 100-mi Western States Endurance Run.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Pulse Wave Velocity: Methodology, Clinical Applications, and Interplay with Heart Rate Variability.Reviews in cardiovascular medicine · 2024Review
- Dynamic changes in glymphatic function in reversible cerebral vasoconstriction syndrome.The journal of headache and pain · 2024Article
- Acute effects of the 4-4-8 breathing technique on arterial stiffness in healthy young men.Cardiology journal · 2024Article
- The 24-h activity cycle and cardiovascular outcomes: establishing biological plausibility using arterial stiffness as an intermediate outcome.American journal of physiology. Heart and circulatory physiology · 2023Review
- Wall Properties of Elastic and Muscular Arteries in Children and Adolescents at Increased Cardiovascular Risk.Journal of clinical medicine · 2023Article
- Temporal longitudinal associations of carotid-femoral pulse wave velocity and carotid intima-media thickness with resting heart rate and inflammation in youth.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Protocol for a study on Sitting with Interruption and Whole-Body Cardiovascular Health (SWITCH) in middle-aged adults.Contemporary clinical trials · 2023Article
- Association Between Arterial Stiffness and Measures of Autonomic Dysfunction in People With Chronic Kidney Disease.Canadian journal of kidney health and disease · 2023Article
- Arterial Stiffness following Endurance and Resistance Exercise Sessions in Older Patients with Coronary Artery Disease.International journal of environmental research and public health · 2022Article
- A Workcation Improves Cardiac Parasympathetic Function during Sleep to Decrease Arterial Stiffness in Workers.Healthcare (Basel, Switzerland) · 2022Article
- Circadian and sex differences in carotid-femoral pulse wave velocity in young individuals and elderly with and without type 2 diabetes.Frontiers in cardiovascular medicine · 2022Article
- Off-Target Effects of Antidepressants on Vascular Function and Structure.Biomedicines · 2021Review
- Clinical Relevance of the Sympathetic-Vascular Interactions in Health and Disease.Biomedicines · 2021Review
- Arterial Stiffness and Hemodynamics in Young Women: The Effects of Oral Contraceptive Intake and Physical Habits.International journal of environmental research and public health · 2021Article
- Effect of Intensity on Changes in Cardiac Autonomic Control of Heart Rate and Arterial Stiffness After Equated Continuous Running Training Programs.Frontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The autonomic nervous system is important in regulating blood pressure, but whether it regulates aortic stiffness is more contentious. We conducted 3 studies in young, healthy individuals to address this important question. Study 1 was a cross-sectional study of 347 subjects with detailed measurements of hemodynamics and heart rate variability. In study 2, 9 subjects were given a bolus of intravenous nicotinic ganglion blocker, pentolinium, or saline in a random order and hemodynamics and heart rate variability were assessed before and after. In study 3, changes in hemodynamics and heart rate variability were assessed during stimulation of the sympathetic nervous system with the use of isometric handgrip exercise in 12 subjects. Study 1: aortic pulse wave velocity (P=0.003) was lowest in the subjects with the highest parasympathetic activity, but after adjusting for mean arterial pressure, the effect was abolished (P=0.3). Study 2: after pentolinium, sympathetic and parasympathetic activity fell (P=0.001 for both), mean arterial pressure, and heart rate increased (P=0.004 and P=0.04, respectively), but there was no change in pulse wave velocity in comparison to placebo (P=0.1). Study 3: during handgrip exercise, sympathetic activity (P=0.003), mean arterial pressure (P<0.0001), and aortic pulse wave velocity increased (P=0.013). However, pulse wave velocity adjusted for mean arterial pressure did not change (P=0.1). The main finding of these studies is that in young healthy subjects, the autonomic nervous system does not have a pressure-independent role in the regulation of aortic stiffness. However, these findings may not apply to patients with increased sympathetic tone or hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.