ReviewAnnals of the New York Academy of Sciences2017
Physiological and molecular responses to bariatric surgery: markers or mechanisms underlying T2DM resolution?
Review in Annals of the New York Academy of Sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Optimal Small Bowel Limb Lengths of Roux-en-Y Gastric Bypass.Current obesity reports · 2023Pooled it
- Molecular Mechanisms Affecting Statin Pharmacokinetics after Bariatric Surgery.International journal of molecular sciences · 2024Review
- Micronutrients in Pregnancy after Bariatric Surgery: A Narrative Review.Journal of clinical medicine · 2023Review
- Gut Factors Mediating the Physiological Impact of Bariatric Surgery.Current diabetes reports · 2022Review
- Effect of sleeve gastrectomy, Roux-en-Y gastric bypass, and ileal transposition on myocardial ischaemia-reperfusion injury in non-obese non-diabetic rats.Scientific reports · 2021Article
- Roux-en-Y Gastric Bypass Surgery Has Early Differential Effects on Bile Acids and the Levels of Complement Component 3 and Acylation-Stimulating Protein.Obesity surgery · 2021Article
- Does Colectomy Improve Type 2 Diabetes?Obesity surgery · 2020Article
- Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations.Diabetology & metabolic syndrome · 2020Article
- Ultra-Early and Early Changes in Bile Acids and Insulin After Sleeve Gastrectomy Among Obese Patients.Medicina (Kaunas, Lithuania) · 2019Article
- Evidence That the Length of Bile Loop Determines Serum Bile Acid Concentration and Glycemic Control After Bariatric Surgery.Obesity surgery · 2018Article
- Effect of Gastrogastric Fistula Closure in Type 2 Diabetes.Obesity surgery · 2018Article
- The impact of bariatric surgery on insulin-treated type 2 diabetes patients.Surgical endoscopy · 2018Article
- Metabolic Surgery in Korea: What to Consider before Surgery.Endocrinology and metabolism (Seoul, Korea) · 2017Review
- The Impact of Bariatric Surgery on Type 2 Diabetes Mellitus and the Management of Hypoglycemic Events.Frontiers in endocrinology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Bariatric surgery is currently the most effective treatment for obesity and associated comorbidities, including rapid resolution of type 2 diabetes mellitus (T2DM). Although the weight loss itself has substantial impact, bariatric surgery also has weight loss-independent effects on T2DM. Several variations of bariatric surgery exist, including the widely studied Roux-en-Y gastric bypass and vertical sleeve gastrectomy. The success of both of these bariatric surgeries was originally attributed to restrictive and malabsorptive modes of action; however, mounting evidence from both human and animal studies implicates mechanisms beyond surgery-induced mechanical changes to the gastrointestinal (GI) system. In fact, with bariatric surgery comes a spectrum of physiological responses, including postprandial enhancement of gut peptide and bile acids levels, restructuring of microbial composition, and changes in GI function and morphology. Although many of these processes are also essential for glucoregulation, the independent role of each in the success of surgery is still an open question. In this review, we explore whether these changes are necessary for the improvements in body mass and glucose homeostasis or whether they are simply markers of the physiological effect of surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.