ArticleScientific reports2016
Characterization of aerosols containing Legionella generated upon nebulization.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- 'Epidemiology ofMicrobial genomics · 2026Article
- The influence of environmental factors on the diversity and structure of airborne fungal and bacterial communities.Mycology · 2026Review
- Host-bacteria interactions: ecological and evolutionary insights from ancient, professional endosymbionts.FEMS microbiology reviews · 2024Review
- A review of pathogenic airborne fungi and bacteria: unveiling occurrence, sources, and profound human health implication.Frontiers in microbiology · 2024Review
- Immunomagnetic separation coupled with flow cytometry for the analysis of Legionella pneumophila in aerosols.Analytical and bioanalytical chemistry · 2023Article
- Effect of temperature and humidity on dynamics and transmission ofFrontiers in plant science · 2023Article
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- A new laser device for ultra-rapid and sustainable aerosol sterilization.Environment international · 2022Article
- Risk Exposure toInternational journal of environmental research and public health · 2022Article
- MIP FromFrontiers in cellular and infection microbiology · 2022Article
- Opportunistic Premise Plumbing Pathogens. A Potential Health Risk in Water Mist Systems Used as a Cooling Intervention.Pathogens (Basel, Switzerland) · 2021Article
- Extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses.NPJ biofilms and microbiomes · 2021Article
- New insights into the standard method of assessing bacterial filtration efficiency of medical face masks.Scientific reports · 2021Article
- Water Sampling Module for Collecting and ConcentratingBiosensors · 2021Article
- Factors InfluencingPathogens (Basel, Switzerland) · 2019Article
- New approach to environmental investigation of an explosive legionnaires´ disease outbreak in Spain: early identification of potential risk sources by rapid Legionella spp immunosensing technique.BMC infectious diseases · 2018Article
- Identifying aerosolized cyanobacteria in the human respiratory tract: A proposed mechanism for cyanotoxin-associated diseases.The Science of the total environment · 2018Article
- Conventional wastewater treatment and reuse site practices modify bacterial community structure but do not eliminate some opportunistic pathogens in reclaimed water.The Science of the total environment · 2018Article
- Evaluation of Exposure toJournal of aerosol science · 2017Article
- Aerobiology: Experimental Considerations, Observations, and Future Tools.Applied and environmental microbiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legionella pneumophila is, by far, the species most frequently associated with Legionnaires' disease (LD). Human infection occurs almost exclusively by aerosol inhalation which places the bacteria in juxtaposition with alveolar macrophages. LD risk management is based on controlling water quality by applying standardized procedures. However, to gain a better understanding of the real risk of exposure, there is a need (i) to investigate under which conditions Legionella may be aerosolized and (ii) to quantify bacterial deposition into the respiratory tract upon nebulization. In this study, we used an original experimental set-up that enables the generation of aerosol particles containing L. pneumophila under various conditions. Using flow cytometry in combination with qPCR and culture, we determined (i) the size of the aerosols and (ii) the concentration of viable Legionella forms that may reach the thoracic region. We determined that the 0.26-2.5 μm aerosol size range represents 7% of initial bacterial suspension. Among the viable forms, 0.7% of initial viable bacterial suspension may reach the pulmonary alveoli. In conclusion, these deposition profiles can be used to standardize the size of inoculum injected in any type of respiratory tract model to obtain new insights into the dose response for LD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.