ArticleScientific reports2016
Biocompatibility and biodistribution of functionalized carbon nano-onions (f-CNOs) in a vertebrate model.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Effects of mechanical properties of carbon-based nanocomposites on scaffolds for tissue engineering applications: a comprehensive review.Nanoscale advances · 2024Review
- Short-Term Intravenous Administration of Carbon Nano-Onions is Non-Toxic in Female Mice.International journal of nanomedicine · 2023Article
- Supramolecular Functionalisation of B/N Co-Doped Carbon Nano-Onions for Novel Nanocarrier Systems.Materials (Basel, Switzerland) · 2022Article
- Identification of microplastics using 4-dimethylamino-4'-nitrostilbene solvatochromic fluorescence.Microscopy research and technique · 2021Article
- Zebrafish: A Promising Real-Time Model System for Nanotechnology-Mediated Neurospecific Drug Delivery.Nanoscale research letters · 2021Review
- Biocompatibility of nanomaterials and their immunological properties.Biomedical materials (Bristol, England) · 2021Review
- Synthesis of green fluorescent carbon dots from carbon nano-onions and graphene oxide.RSC advances · 2020Article
- Surface Modification of Magnetic Nanoparticles by Carbon-Coating Can Increase Its Biosafety: Evidences from Biochemical and Neurobehavioral Tests in Zebrafish.Molecules (Basel, Switzerland) · 2020Article
- Modulation of Efficient Diiodo-BODIPYFrontiers in chemistry · 2020Article
- Carbon Nano-Onions as Non-Cytotoxic Carriers for Cellular Uptake of Glycopeptides and Proteins.Nanomaterials (Basel, Switzerland) · 2019Article
- Combined study of the ground and excited states in the transformation of nanodiamonds into carbon onions by electron energy-loss spectroscopy.Scientific reports · 2019Article
- Zebrafish as a Model to Evaluate Nanoparticle Toxicity.Nanomaterials (Basel, Switzerland) · 2018Review
- The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity.Frontiers in neuroscience · 2018Review
- Toxicity Assessment of Carbon Nanomaterials in Zebrafish during Development.Nanomaterials (Basel, Switzerland) · 2017Article
- Carbon nano-onions as fluorescent on/off modulated nanoprobes for diagnostics.Beilstein journal of nanotechnology · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functionalized carbon nano-onions (f-CNOs) are of great interest as platforms for imaging, diagnostic and therapeutic applications due to their high cellular uptake and low cytotoxicity. To date, the toxicological effects of f-CNOs on vertebrates have not been reported. In this study, the possible biological impact of f-CNOs on zebrafish during development is investigated, evaluating different toxicity end-points such as the survival rate, hatching rate, and heart beat rate. Furthermore, a bio-distribution study of boron dipyrromethene (BODIPY) functionalized CNOs in zebrafish larvae is performed by utilizing inverted selective plane illumination microscopy (iSPIM), due to its intrinsic capability of allowing for fast 3D imaging. Our in vivo findings indicate that f-CNOs exhibit no toxicity, good biocompatibility (in the concentration range of 5-100 μg mL
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Registered trials
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