ArticleRadiation oncology (London, England)2016
A treatment planning study comparing tomotherapy, volumetric modulated arc therapy, Sliding Window and proton therapy for low-risk prostate carcinoma.
Article in Radiation oncology (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- The influence of hepatic arterial blood flow rate on holmium microsphere distribution: an MRI study in perfused porcine livers.European radiology experimental · 2025Article
- From CBCT to MR-Linac in Image-Guided Prostate Cancer Radiotherapy Towards Treatment Personalization.Current oncology (Toronto, Ont.) · 2025Review
- Effectiveness of robust optimization against geometric uncertainties in TomoHelical planning for prostate cancer.Journal of applied clinical medical physics · 2023Article
- Proton therapy for prostate cancer: current state and future perspectives.The British journal of radiology · 2022Review
- Prostate Cancer Treatment with Pencil Beam Proton Therapy Using Rectal Spacers sans Endorectal Balloons.International journal of particle therapy · 2022Article
- Proton therapy- the modality of choice for future radiation therapy management of Prostate Cancer?Technical innovations & patient support in radiation oncology · 2019Review
- The heterogeneous CTV-PTV margins should be given for different parts of tumors during tomotherapy.Oncotarget · 2017Article
- Prostate Cancer Radiation Therapy: What Do Clinicians Have to Know?BioMed research international · 2016Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComparing radiation treatment plans to ascertain the optimal intensity-modulated radiation technique for low-risk prostate cancer.
methodsTreatment plans for 20 randomly selected patients were generated using the same dose objectives. A dosimetric comparison was performed between various intensity-modulated techniques, including protons. All treatment plans provided conventional treatment with 79.2Gy. Dosimetric indices for the target volume and organs at risk (OAR), including homogeneity index and four conformity indices were analyzed.
resultsNo statistically significant differences between techniques were observed for homogeneity values. Dose distributions showed significant differences at low-to-medium doses. At doses above 50Gy all techniques revealed a steep dose gradient outside the planning target volume (PTV). Protons demonstrated superior rectum sparing at low-to-higher doses (V10-V70, P < .05) and bladder sparing at low-to-medium doses (V10-V30, P < .05). Helical tomotherapy (HT) provided superior rectum sparing compared to Sliding Window (SW) and Rapid Arc (RA) (V10-V70, P < .05). SW displayed superior bladder sparing compared to HT and RA (V10-V50, P < .05). Protons generated significantly higher femoral heads exposure and HT had superior sparing of those.
conclusionAll techniques are able to provide a homogeneous and highly conformal dose distribution. Protons demonstrated superior sparing of the rectum and bladder at a wide dose spectrum. The radiation technique itself as well as treatment planning algorithms result in different OAR sparing between HT, SW and RA, with superior rectum sparing by HT and superior bladder sparing by SW. Radiation plans can be further optimized by individual modification of dose objectives dependent on treatment plan strategy.
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