ArticleCancer prevention research (Philadelphia, Pa.)2016
Molecular Triage of Premalignant Lesions in Liquid-Based Cervical Cytology and Circulating Cell-Free DNA from Urine, Using a Panel of Methylated Human Papilloma Virus and Host Genes.
2 registry-linked trialsAbstract read
In one paragraph
Article in Cancer prevention research (Philadelphia, Pa.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Case-control Study of the Clinical Utility of DNA Methylation Testing in Patient-collected Vaginal and Urine Samples: A Novel, Patient-friendly and Simple Diagnostic Solution to Detect Endometrial Cancer.
The ENDOMETRIAL Study: EvaluatioN of DNA methylatiOn Markers for EndomeTrial Cancer Risk-stratification Using Patient-collected urIne and vAginal Samples and Clinician-collected Cervical Samples From Women With Postmenopausal bLeeding
Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Observational
- Clinical performance of ASCL1/LHX8 DNA methylation on first-void urine to screen for cervical cancer.Communications medicine · 2026Article
- CervicalMethDx: A Precision DNA Methylation Test to Identify Risk of High-Grade Intraepithelial Lesions in Cervical Cancer Screening Algorithms.Cancer prevention research (Philadelphia, Pa.) · 2025Article
- Unlocking the potential of tumor-derived DNA in urine for cancer detection: methodological challenges and opportunities.Molecular oncology · 2025Review
- The role of circulating tumor DNA in gynecological cancer management.Frontiers in oncology · 2025Review
- Cervical Cancer Genetic Profile through Circulating Tumor DNA: What Can We Learn from Blood?Biomolecules · 2024Review
- DNA methylation as a triage tool for cervical cancer screening - A meeting report.Preventive medicine reports · 2024Review
- Promoter DNA methylation patterns in oral, laryngeal and oropharyngeal anatomical regions are associated with tumor differentiation, nodal involvement and survival.Oncology letters · 2024Article
- Phenotypic Heterogeneity, Bidirectionality, Universal Cues, Plasticity, Mechanics, and the Tumor Microenvironment Drive Cancer Metastasis.Biomolecules · 2024Review
- Advancements in the clinical application of gene methylation for early cancer detection.Frontiers in epigenetics and epigenomics · 2024Review
- Beyond liquid biopsy: Toward non-invasive assays for distanced cancer diagnostics in pandemics.Biosensors & bioelectronics · 2022Review
- Mitochondria dysfunction in circulating tumor cells.Frontiers in oncology · 2022Review
- Liquid Biopsy in Cervical Cancer: Hopes and Pitfalls.Cancers · 2021Review
- Triage of human papillomavirus infected women by methylation analysis in first-void urine.Scientific reports · 2021Article
- Article
- Methylation analysis in urine fractions for optimal CIN3 and cervical cancer detection.Papillomavirus research (Amsterdam, Netherlands) · 2020Article
- Cervical cancer detection by DNA methylation analysis in urine.Scientific reports · 2019Article
- Clinical epigenetics: seizing opportunities for translation.Nature reviews. Genetics · 2019Review
- Candidate biomarkers in the cervical vaginal fluid for the (self-)diagnosis of cervical precancer.Archives of gynecology and obstetrics · 2018Review
- Detection and genotyping of human papillomavirus virus (HPV): a comparative analysis of clinical performance in cervical and urine samples in Chilean women.International journal of clinical and experimental pathology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 1 institution in 1 country.
Rafael Guerrero-PrestonJohns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland. rguerre3@jhmi.edu dsidrans@jhmi.edu.
Blanca L ValleJohns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland.
Anne JedlickaJohns Hopkins University School of Public Health, Department of Molecular Microbiology, Baltimore, Maryland.
Nitesh TuragaJohns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland.
Oluwasina FolawiyoJohns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland.
Francesca PiriniJohns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland.
Fahcina LawsonJohns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland.
Angelo VerguraJohns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland.
Maartje NoordhuisJohns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland.
Amanda DziedzicJohns Hopkins University School of Public Health, Department of Molecular Microbiology, Baltimore, Maryland.
Gabriela PérezJohns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland.
Marisa RenehanJohns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland.
Carolina Guerrero-DiazJohns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland.
Edgar De Jesus RodríguezUniversity of Puerto Rico School of Medicine, Department of Obstetrics and Gynecology, San Juan, Puerto Rico.
Teresa Diaz-MontesThe Institute for Cancer Care at Mercy, Department of Obstetrics and Gynecology, Baltimore, Maryland.
José Rodríguez OrengoUniversity of Puerto Rico School of Medicine, Department of Biochemistry, San Juan, Puerto Rico.
Keimari MéndezUniversity of Puerto Rico School of Medicine, Department of Obstetrics and Gynecology, San Juan, Puerto Rico.
Josefina RomagueraUniversity of Puerto Rico School of Medicine, Department of Obstetrics and Gynecology, San Juan, Puerto Rico.
Bruce J TrockJohns Hopkins School of Medicine, Brady Urological Institute, Baltimore, Maryland.
Liliana FloreaJohns Hopkins School of Medicine, McKusick-Nathans Institute of Genetic Medicine, Baltimore, Maryland.
David SidranskyJohns Hopkins University School of Medicine, Department of Otolaryngology, Baltimore, Maryland. rguerre3@jhmi.edu dsidrans@jhmi.edu.
Dialyse Centrum Groningen · NL
Funding
INTEGRATED DEVELOPMENT OF NOVEL MOLECULAR MARKERSU01CA084986 · NCI · JOHNS HOPKINS UNIVERSITY · PI SIDRANSKY, DAVID · 1999 to 2014
$33.8MEpigenomic Markers of HNSCC Survival Across Ethnic GroupsK01CA164092 · NCI · JOHNS HOPKINS UNIVERSITY · PI GUERRERO-PRESTON, RAFAEL · 2011 to 2014
$530kNCI NIH HHS K01 CA164092NCI NIH HHS U01 CA084986
Abstract
Clinically useful molecular tools to triage women for a biopsy upon referral to colposcopy are not available. We aimed to develop a molecular panel to detect cervical intraepithelial neoplasia (CIN) grade 2 or higher lesions (CIN2
Indexed as
DNA MethylationAdolescentAdultAgedAged, 80 and overBiomarkers, TumorBiopsyCohort StudiesColposcopyDNA-Binding ProteinsDNA, ViralFemaleHuman papillomavirus 16Human Papillomavirus DNA TestsHumansMiddle AgedBiomarkers, TumorDNA-Binding ProteinsDNA, ViralFKBP6 protein, humanL1(deltaN26)-E7(deltaC38) protein, HPV16Tacrolimus Binding ProteinsVaccines, Virus-Like ParticleWnt1 ProteinWNT1 protein, humanZNF516 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT06846775ClinicalTrials.gov
NCT07400835ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.