ArticleJournal of the American Heart Association2016
Role of Early Repolarization Pattern in Increasing Risk of Death.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Risk and Protective Factors for Sudden Cardiac Death: An Umbrella Review of Meta-Analyses.Frontiers in cardiovascular medicine · 2022Pooled it
- KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern.JCI insight · 2019Pooled it
- Primary Electrical Heart Disease-Principles of Pathophysiology and Genetics.International journal of molecular sciences · 2024Review
- Outcome of patients with idiopathic ventricular fibrillation and correlation with ECG markers of early repolarization.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Role of Gut Microbiome in Atherosclerosis: Molecular and Therapeutic Aspects.Current cardiology reviews · 2023Review
- Early repolarization in adolescent athletes: A gender comparison of ECG and echocardiographic characteristics.Scandinavian journal of medicine & science in sports · 2022Article
- Association Between Temporal Changes in Early Repolarization Pattern With Long-Term Cardiovascular Outcome: A Population-Based Cohort Study.Journal of the American Heart Association · 2022Article
- Cardiocerebral channelopathy caused byFrontiers in pediatrics · 2022Article
- Evaluation of Early Repolarization Pattern in Male Teenage Competitive Athletes and Association With Left Ventricular Remodeling.Turkish archives of pediatrics · 2021Article
- JCS/JHRS 2019 guideline on non-pharmacotherapy of cardiac arrhythmias.Journal of arrhythmia · 2021Article
- Article
- Left ventricular geometry and function in early repolarization: results from the population-based Gutenberg Health Study.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Observational
- Prevalence of early repolarization syndrome and long-term clinical outcome in patients with the diagnosis of idiopathic ventricular fibrillation.Heart and vessels · 2019Article
- The early repolarization pattern: Echocardiographic characteristics in elite athletes.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2019Article
- Ion Channel Disorders and Sudden Cardiac Death.International journal of molecular sciences · 2018Review
- The Electrophysiological Substrate of Early Repolarization Syndrome: Noninvasive Mapping in Patients.JACC. Clinical electrophysiology · 2017Article
- Long-Term Cardiovascular Risk After Radiotherapy in Women With Breast Cancer.Journal of the American Heart Association · 2017Review
- Baseline ST elevation and myocardial scar: Results from the multi-ethnic study of atherosclerosis.Journal of electrocardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn early repolarization pattern (ERP) has been hypothesized to be arrhythmogenic in experimental studies, but the prognostic significance of the ERP in the general population is controversial. We performed a meta-analysis to examine the link between ERP and the risk of sudden cardiac arrest (SCA), cardiac death, and death from any cause. METHODS AND
resultsWe performed a literature search using MEDLINE (January 1, 1966 to July 31, 2015) and EMBASE (January 1, 1980 to July 31, 2015) with no restrictions. Studies that reported relative risk (RR) estimates with 95% confidence intervals (CIs) for the associations of interest were included. Sixteen studies involving 334 524 subjects were identified. Compared with those without ERP, subjects with ERP experienced significantly increased risk for developing SCA (RR 2.18; 95% CI 1.29-3.68), cardiac death (RR 1.48; 95% CI 1.06-2.07), and death from any cause (RR 1.21; 95% CI 1.02-1.42), respectively. The increased risk was present predominantly in Asians and whites but not in African Americans. ERP with J-point elevation in inferior leads, notching configuration, and horizontal or descending ST segment connote higher risk. ERP was associated with an absolute risk increase of 139.6 (95% CI 130.3-149.3) additional SCAs per 100 000 person-years and responsible for 7.3% (95% CI 1.9-15.2) of SCA in the general population.
conclusionsERP is associated with significant increased risk for SCA, cardiac death, and death from any cause. Future studies should focus on understanding the exact mechanisms for the arrhythmia risk and developing reliable tools for risk stratification.
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Registered trials
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