ArticleScientific reports2016
Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Mechanical state transitions in the regulation of tissue form and function.Nature reviews. Molecular cell biology · 2024Review
- Design optimization of geometrically confined cardiac organoids enabled by machine learning techniques.Cell reports methods · 2024Article
- Light-driven biological actuators to probe the rheology of 3D microtissues.Nature communications · 2023Article
- Controlling Mesenchyme Tissue Remodeling via Spatial Arrangement of Mechanical Constraints.Frontiers in bioengineering and biotechnology · 2022Article
- Integrating mechanical sensor readouts into organ-on-a-chip platforms.Frontiers in bioengineering and biotechnology · 2022Review
- Revisiting tissue tensegrity: Biomaterial-based approaches to measure forces across length scales.APL bioengineering · 2021Review
- Recursive feedback between matrix dissipation and chemo-mechanical signaling drives oscillatory growth of cancer cell invadopodia.Cell reports · 2021Article
- Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics.Frontiers in cell and developmental biology · 2021Review
- Review
- Structural and mechanical remodeling of the cytoskeleton maintains tensional homeostasis in 3D microtissues under acute dynamic stretch.Scientific reports · 2020Article
- Multi-scale cellular engineering: From molecules to organ-on-a-chip.APL bioengineering · 2020Article
- Induced pluripotent stem cell-derived vascular smooth muscle cells.Vascular biology (Bristol, England) · 2020Review
- The plakin domain ofDevelopment (Cambridge, England) · 2019Article
- Helical nanofiber yarn enabling highly stretchable engineered microtissue.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Physics of growing biological tissues: the complex cross-talk between cell activity, growth and resistance.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019Review
- Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices.PLoS computational biology · 2019Article
- Energy dissipation in quasi-linear viscoelastic tissues, cells, and extracellular matrix.Journal of the mechanical behavior of biomedical materials · 2018Article
- Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces.Biophysical journal · 2018Article
- Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The biomechanical behavior of tissues under mechanical stimulation is critically important to physiological function. We report a combined experimental and modeling study of bioengineered 3D smooth muscle microtissues that reveals a previously unappreciated interaction between active cell mechanics and the viscoplastic properties of the extracellular matrix. The microtissues' response to stretch/unstretch actuations, as probed by microcantilever force sensors, was dominated by cellular actomyosin dynamics. However, cell lysis revealed a viscoplastic response of the underlying model collagen/fibrin matrix. A model coupling Hill-type actomyosin dynamics with a plastic perfectly viscoplastic description of the matrix quantitatively accounts for the microtissue dynamics, including notably the cells' shielding of the matrix plasticity. Stretch measurements of single cells confirmed the active cell dynamics, and were well described by a single-cell version of our model. These results reveal the need for new focus on matrix plasticity and its interactions with active cell mechanics in describing tissue dynamics.
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Registered trials
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