Evidence map›Paper›PMID 27671161›Full record

ReviewLipids2016

Assessment of Isoprostanes in Human Plasma: Technical Considerations and the Use of Mass Spectrometry.

Yiu Yiu Lee, Jean-Marie Galano, Camille Oger, Claire Vigor, Reversat Guillaume, Jérôme Roy, Jean-Yves Le Guennec, Thierry Durand, Jetty Chung-Yung Lee

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Lipids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Yiu Yiu LeeSchool of Biological Sciences, The University of Hong Kong, Hong Kong, Hong Kong SAR.
Jean-Marie GalanoInstitut des Biomolécules Max Mousseron, UMR 5247 CNRS, ENSCM, Université de Montpellier, Montpellier, France.
Camille OgerInstitut des Biomolécules Max Mousseron, UMR 5247 CNRS, ENSCM, Université de Montpellier, Montpellier, France.
Claire VigorInstitut des Biomolécules Max Mousseron, UMR 5247 CNRS, ENSCM, Université de Montpellier, Montpellier, France.
Reversat GuillaumeInstitut des Biomolécules Max Mousseron, UMR 5247 CNRS, ENSCM, Université de Montpellier, Montpellier, France.
Jérôme RoyUMR CNRS 9214-Inserm U1046 Physiologie et Médecine Expérimentale du cœur et des muscles-PHYMEDEXP, Université de Montpellier, Montpellier, France.
Jean-Yves Le GuennecUMR CNRS 9214-Inserm U1046 Physiologie et Médecine Expérimentale du cœur et des muscles-PHYMEDEXP, Université de Montpellier, Montpellier, France.
Thierry DurandInstitut des Biomolécules Max Mousseron, UMR 5247 CNRS, ENSCM, Université de Montpellier, Montpellier, France.
Jetty Chung-Yung LeeSchool of Biological Sciences, The University of Hong Kong, Hong Kong, Hong Kong SAR. jettylee@hku.hk.ORCID 0000-0002-8175-7069
Institut des Biomolécules Max Mousseron · FRÉcole Nationale Supérieure de Chimie de Montpellier · FREducation University of Hong Kong · HKInserm · FRPhysiologie et Médecine Expérimentale du Coeur et des Muscles · FRUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxygenated lipid mediators released from non-enzymatic peroxidation of polyunsaturated fatty acids (PUFA) are known to have functional roles in humans. Notably, among these lipid mediators, isoprostanes molecules are robust biomarkers of oxidative stress but those from n-3 PUFA are also bioactive molecules. In order to identify and assess the isoprostanes, the use of mass spectrometry (MS) for analysis is preferable and has been used for over two decades. Gas chromatography (GC) is commonly coupled to the MS to separate the derivatized isoprostanes of interest in biological samples. In order to increase the accuracy of the analytical performance, GC-MS/MS was also applied. Lately, MS or MS/MS has been coupled with high-performance liquid chromatography to assess multiple isoprostane molecules in a single biological sample without derivatization process. However, there are limitations for the use of LC-MS/MS in the measurement of plasma isoprostanes, which will be discussed in this review.

Indexed as

Chromatography, High Pressure LiquidGas Chromatography-Mass SpectrometryHumansIsoprostanesLipid PeroxidationTandem Mass SpectrometryIsoprostanesGC–MSIsoprostanesLC–MS/MSLipid peroxidationNeuroprostanes

Identifiers

PMID27671161
OpenAlexW2526333124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.