ArticlePlant physiology2016
The Genetics of Leaf Flecking in Maize and Its Relationship to Plant Defense and Disease Resistance.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- The maize mitogen-activated protein kinase kinase kinase gene ZmMAPKKK45 is associated with multiple disease resistance.The New phytologist · 2026Article
- Durum wheat mutants with enhanced disease resistance to stripe rust show differential responses to other fungal diseases.Molecular breeding : new strategies in plant improvement · 2025Article
- Special issue: Genetics of maize-microbe interactions.Molecular plant pathology · 2023Article
- Elucidating the patterns of pleiotropy and its biological relevance in maize.PLoS genetics · 2023Article
- Brown midrib mutant and genome-wide association analysis uncover lignin genes for disease resistance in maize.The plant genome · 2023Article
- Advances in Understanding Defense Mechanisms inFrontiers in plant science · 2021Review
- The plant hypersensitive response: concepts, control and consequences.Molecular plant pathology · 2019Review
- A maize polygalacturonase functions as a suppressor of programmed cell death in plants.BMC plant biology · 2019Article
- AG3 (Bethesda, Md.) · 2019Article
- Image-Derived Traits Related to Mid-Season Growth Performance of Maize Under Nitrogen and Water Stress.Frontiers in plant science · 2019Article
- Survey of Candidate Genes for Maize Resistance to Infection by Aspergillus flavus and/or Aflatoxin Contamination.Toxins · 2018Article
- Navigating complexity to breed disease-resistant crops.Nature reviews. Genetics · 2018Review
- Genetic dissection of the maize (Zea mays L.) MAMP response.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physiological leaf spotting, or flecking, is a mild-lesion phenotype observed on the leaves of several commonly used maize (Zea mays) inbred lines and has been anecdotally linked to enhanced broad-spectrum disease resistance. Flecking was assessed in the maize nested association mapping (NAM) population, comprising 4,998 recombinant inbred lines from 25 biparental families, and in an association population, comprising 279 diverse maize inbreds. Joint family linkage analysis was conducted with 7,386 markers in the NAM population. Genome-wide association tests were performed with 26.5 million single-nucleotide polymorphisms (SNPs) in the NAM population and with 246,497 SNPs in the association population, resulting in the identification of 18 and three loci associated with variation in flecking, respectively. Many of the candidate genes colocalizing with associated SNPs are similar to genes that function in plant defense response via cell wall modification, salicylic acid- and jasmonic acid-dependent pathways, redox homeostasis, stress response, and vesicle trafficking/remodeling. Significant positive correlations were found between increased flecking, stronger defense response, increased disease resistance, and increased pest resistance. A nonlinear relationship with total kernel weight also was observed whereby lines with relatively high levels of flecking had, on average, lower total kernel weight. We present evidence suggesting that mild flecking could be used as a selection criterion for breeding programs trying to incorporate broad-spectrum disease resistance.
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