Observational studyThe American journal of cardiology2016
Relation of Statin Use and Mortality in Community-Dwelling Frail Older Patients With Coronary Artery Disease.
Observational study in The American journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Association between Statins Prescribed for Primary and Secondary Prevention and Major Adverse Cardiac Events among Older Adults with Frailty: A Systematic Review.Drugs & aging · 2020 · on this mapPooled it
- Appropriateness and Outcome of a Statin Deprescription Intervention in Hospitalized Frail Older Adults: A Retrospective Study.Geriatrics (Basel, Switzerland) · 2026Article
- In the wake of the Scandinavian Simvastatin Survival Study trial.Current opinion in lipidology · 2025Review
- Usefulness of a new digital version of the MPI-SVaMA (MPI-SVaMA Digit) in predicting short- and long-term mortality in community-dwelling older people.Aging clinical and experimental research · 2025Article
- Hippocratic considerations about statin treatment for patients over 75 years of age.European geriatric medicine · 2025Article
- Synergistic mediating effect of edible fungal polysaccharides (Food science & nutrition · 2023Article
- Observational
- FIB-4 Index and Neutrophil-to-Lymphocyte-Ratio as Death Predictor in Coronary Artery Disease Patients.Biomedicines · 2022Article
- A Propensity Score Matched Analysis of Statin Effects on Major Adverse Cardiac Events after Percutaneous Coronary Intervention in Patients Over 75 Years Old.Internal medicine (Tokyo, Japan) · 2022Article
- Can the Multidimensional Prognostic Index Improve the Identification of Older Hospitalized Patients with COVID-19 Likely to Benefit from Mechanical Ventilation? An Observational, Prospective, Multicenter Study.Journal of the American Medical Directors Association · 2022Observational
- Multidimensional Prognostic Index (MPI) in elderly patients with acute myocardial infarction.Aging clinical and experimental research · 2021Article
- Multidimensional Prognostic Index and Mortality in Intermediate Care Facilities: A Retrospective Study.Journal of clinical medicine · 2021Article
- The challenge of the multifaceted prognosis in the older people and the Multidimensional Prognostic Index.European geriatric medicine · 2021Article
- A multidimensional approach to frailty in older people.Ageing research reviews · 2020Review
- Frailty and coronary plaque characteristics on optical coherence tomography.Heart and vessels · 2020Article
- Using the Multidimensional Prognostic Index (MPI) to improve cost-effectiveness of interventions in multimorbid frail older persons: results and final recommendations from the MPI_AGE European Project.Aging clinical and experimental research · 2020Review
- Impact of age on cardiovascular drug use in patients with chronic kidney disease.Clinical kidney journal · 2020Article
- Statin treatment, phenotypic frailty and mortality among community-dwelling octogenarian men: the HBS cohort.Age and ageing · 2020Article
- Validation and Adaptation of the Multidimensional Prognostic Index in an Older Australian Cohort.Journal of clinical medicine · 2019Article
- Article
Corrections and comments
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Authors and funding
18 authors at 15 institutions in 9 countries.
Funding
Abstract
Clinical decision-making for statin treatment in older patients with coronary artery disease (CAD) is under debate, particularly in community-dwelling frail patients at high risk of death. In this retrospective observational study on 2,597 community-dwelling patients aged ≥65 years with a previous hospitalization for CAD, we estimated mortality risk assessed with the Multidimensional Prognostic Index (MPI), based on the Standardized Multidimensional Assessment Schedule for Adults and Aged Persons (SVaMA), used to determine accessibility to homecare services/nursing home admission in 2005 to 2013 in the Padua Health District, Veneto, Italy. Participants were categorized as having mild (MPI-SVaMA-1), moderate (MPI-SVaMA-2), and high (MPI-SVaMA-3) baseline mortality risk, and propensity score-adjusted hazard ratios (HRs) of 3-year mortality rate were calculated according to statin treatment in these subgroups. Greater MPI-SVaMA scores were associated with lower rates of statin treatment and higher 3-year mortality rate (MPI-SVaMA-1 = 23.4%; MPI-SVaMA-2 = 39.1%; MPI-SVaMA-3 = 76.2%). After adjusting for propensity score quintiles, statin treatment was associated with lower 3-year mortality risk irrespective of MPI-SVaMA group (HRs [95% confidence intervals] 0.45 [0.37 to 0.55], 0.44 [0.36 to 0.53], and 0.28 [0.21 to 0.39] in MPI-SVaMA-1, -2, and -3 groups, respectively [interaction test p = 0.202]). Subgroup analyses showed that statin treatment was also beneficial irrespective of age (HRs [95% confidence intervals] 0.38 [0.27 to 0.53], 0.45 [0.38 to 0.54], and 0.44 [0.37 to 0.54] in 65 to 74, 75 to 84, and ≥85 year age groups, respectively [interaction test p = 0.597]). In conclusion, in community-dwelling frail older patients with CAD, statin treatment was significantly associated with reduced 3-year mortality rate irrespective of age and multidimensional impairment, although the frailest patients were less likely to be treated with statins.
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Registered trials
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