Evidence map›Paper›PMID 27670714›Full record

ArticleJournal of molecular biology2016

New Insights into the Phage Genetic Switch: Effects of Bacteriophage Lambda Operator Mutations on DNA Looping and Regulation of P

Dale E A Lewis, Gary N Gussin, Sankar Adhya

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Dale E A LewisLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA.
Gary N GussinDepartment of Biology, University of Iowa, Iowa City, IA 52242, USA.
Sankar AdhyaLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. Electronic address: sadhya@helix.nih.gov.
National Institutes of Health · USUniversity of Iowa · US

Funding

Regulation of Gene TranscriptionZIABC008751 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ADHYA, SANKAR · 2009 to 2025
$24.3M
Using Bacteriophages to Prevent, Diagnose, and Treat DiseasesZ01BC010017 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ADHYA, SANKAR · 1996 to 2008
$878k
Intramural NIH HHS Z01 BC010017
6 · The paper itself

Abstract

One of the best understood systems in genetic regulatory biology is the so-called "genetic switch" that determines the choice the phage-encoded CI repressor binds cooperatively to tripartite operators, O

Indexed as

Gene Expression Regulation, ViralNucleic Acid ConformationOperator Regions, GeneticPromoter Regions, GeneticBacteriophage lambdaDNA, ViralLysogenyMutationProtein BindingRepressor ProteinsTranscription, GeneticVirus ActivationDNA, ViralRepressor ProteinsCI repressorDNA loopinggenetic switchprophage lambdatranscription

Identifiers

PMID27670714
PMCPMC7757127
OpenAlexW2521863855

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.