Evidence map›Paper›PMID 27670633›Full record

ArticleMagnetic resonance in medicine2017

Evaluation of non-Gaussian diffusion in cardiac MRI.

Darryl McClymont, Irvin Teh, Eric Carruth, Jeffrey Omens, Andrew McCulloch, Hannah J Whittington, Peter Kohl, Vicente Grau, Jürgen E Schneider

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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  8. Regional variations in ex-vivo diffusion tensor anisotropy are associated with cardiomyocyte remodeling in rats after left ventricular pressure overload.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Article
  9. Diffusion kurtosis imaging provides quantitative assessment of the microstructure changes of disc degeneration: an in vivo experimental study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Darryl McClymontDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Irvin TehDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Eric CarruthDepartment of Bioengineering, University of California-San Diego, La Jolla, California, USA.
Jeffrey OmensDepartment of Bioengineering, University of California-San Diego, La Jolla, California, USA.
Andrew McCullochDepartment of Bioengineering, University of California-San Diego, La Jolla, California, USA.
Hannah J WhittingtonDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Peter KohlNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Vicente GrauDepartment of Engineering Science, University of Oxford, Oxford, United Kingdom.
Jürgen E SchneiderDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
University of Oxford · GBUniversity of California San Diego · USLa Jolla Bioengineering Institute · USScience Oxford · GBUniversity of Freiburg · DE

Funding

The Virtual Physiological Rat ProjectP50GM094503 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BEARD, DANIEL A · 2011 to 2015
$11.6M
Integrative Bioengineering of Heart, Vessels, and BloodT32HL105373 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, INTAGLIETTA, MARCOS · 2010 to 2019
$3.6M
Systems Biology of Hypertrophic Heart Disease from Molecular Pathways to Organ SystemR01HL137100 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCULLOCH, ANDREW D. · 2017 to 2020
$2.0M
British Heart Foundation FS/11/50/29038British Heart Foundation FS/12/17/29532British Heart Foundation NH/13/30238British Heart Foundation PG/13/33/30210British Heart Foundation RE/13/1/30181British Heart Foundation RG/13/8/30266NHLBI NIH HHS R01 HL137100NHLBI NIH HHS T32 HL105373NIGMS NIH HHS P50 GM094503Wellcome TrustWellcome Trust 090532/Z/09/Z
6 · The paper itself

Abstract

purposeThe diffusion tensor model assumes Gaussian diffusion and is widely applied in cardiac diffusion MRI. However, diffusion in biological tissue deviates from a Gaussian profile as a result of hindrance and restriction from cell and tissue microstructure, and may be quantified better by non-Gaussian modeling. The aim of this study was to investigate non-Gaussian diffusion in healthy and hypertrophic hearts.

methodsThirteen rat hearts (five healthy, four sham, four hypertrophic) were imaged ex vivo. Diffusion-weighted images were acquired at b-values up to 10,000 s/mm

resultsThe diffusion tensor was ranked best at b-values up to 2000 s/mm

conclusionNon-Gaussian diffusion models have a higher sensitivity for the detection of hypertrophy compared with the Gaussian model. In particular, diffusion kurtosis may serve as a useful biomarker for characterization of disease and remodeling in the heart. Magn Reson Med 78:1174-1186, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Indexed as

AlgorithmsAnimalsCardiomegalyDiffusion Magnetic Resonance ImagingHeartImage Processing, Computer-AssistedMaleNormal DistributionRatsRats, Sprague-Dawleycardiac MRIdiffusion tensor imaginghypertrophykurtosisnon-Gaussiantissue characterization

Identifiers

PMID27670633
PMCPMC5366286
OpenAlexW2529656509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.