ArticleHeart rhythm2017
Simultaneous noninvasive recording of skin sympathetic nerve activity and electrocardiogram.
Article in Heart rhythm, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using Skin Sympathetic Nerve Activity to Estimate Sympathetic Tone in Human
Crystalloid Versus Colloid Rapid Co-load in Parturients Receiving Prophylactic Phenylephrine Infusion During Cesarean Delivery Under Spinal Anesthesia
Who cites it
70 citing papers in PubMed, 141 citations in OpenAlex.
- Acute Effects of Resonance Breathing on Skin Sympathetic Nerve Activity and Heart Rate Variability in Healthy Adults.Applied psychophysiology and biofeedback · 2025Trial
- Simultaneous noninvasive recording of electrocardiogram and skin sympathetic nerve activity (neuECG).Nature protocols · 2020Trial
- Resting skin sympathetic nerve activity spectral characteristics are associated with orthostatic sympathetic responses and exaggerated orthostatic pressor response in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Complexity Analysis of Skin Nerve Activity for Quantitative Assessment of Acute Sympathetic Nervous System Activation.Sensors (Basel, Switzerland) · 2026Article
- Respiratory modulation of neurophysiology and symptoms in athletes with sports-related concussion: a randomized crossover trial.Frontiers in neuroscience · 2026Article
- Interplay between Skin Sympathetic Nerve Activity and Gut Microbiota, the Neurocardiac Axis in Acute Coronary Syndrome.International journal of medical sciences · 2026Article
- Prediction of intradialytic hypotension based on heart rate variability and skin sympathetic nerve activity using LASSO-enabled feature selection: a two-center study.Renal failure · 2025Article
- Pupillary ultrasonography vs Horner's syndrome to evaluate efficacy of stellate ganglion block in patients.IBRO neuroscience reports · 2025Article
- Autonomic dysregulation and atrial arrhythmias.American journal of physiology. Cell physiology · 2025Review
- Improved non-invasive detection of sleep stages when combining skin sympathetic nerve activity and heart rate variability analysis with AI.Scientific reports · 2025Article
- Triglyceride-glucose index is associated with silent cerebral infarcts in patients with atrial fibrillation undergoing catheter ablation.BMC cardiovascular disorders · 2025Article
- Antiarrhythmic effects of mirabegron on ventricular fibrillation in Langendorff-perfused rabbit ventricles.The Journal of physiology · 2025Article
- lncRNA-056298 Regulates GAP43 and Promotes Cardiac Intrinsic Autonomic Nerve Remodelling in a Canine Model of Atrial Fibrillation Induction after Ganglionated Plexus Ablation.Current medicinal chemistry · 2025Article
- Autonomic Nervous Regulation was Associated with Sleep Quality Among Peritoneal Dialysis Patients.Nature and science of sleep · 2025Article
- Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage.Physiological reports · 2025Article
- Skin sympathetic nerve activity in symptomatic and asymptomatic paroxysmal atrial fibrillation.Heart rhythm · 2024Article
- Torsades de Pointes electrical storm in children with KCNH2 mutations.BMC medical genomics · 2024Article
- Renal autonomic dynamics in hypertension: how can we evaluate sympathetic activity for renal denervation?Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Skin sympathetic nerve activity and ST-segment depression in women.Heart rhythm O2 · 2024Article
- Advancing spinal cord injury care through non-invasive autonomic dysreflexia detection with AI.Scientific reports · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundSympathetic nerve activity is important to cardiac arrhythmogenesis.
objectiveThe purpose of this study was to develop a method for simultaneous noninvasive recording of skin sympathetic nerve activity (SKNA) and electrocardiogram (ECG) using conventional ECG electrodes. This method (neuECG) can be used to adequately estimate sympathetic tone.
methodsWe recorded neuECG signals from the skin of 56 human subjects. The signals were low-pass filtered to show the ECG and high-pass filtered to show nerve activity. Protocol 1 included 12 healthy volunteers who underwent cold water pressor test and Valsalva maneuver. Protocol 2 included 19 inpatients with epilepsy but without known heart diseases monitored for 24 hours. Protocol 3 included 22 patients admitted with electrical storm and monitored for 39.0 ± 28.2 hours. Protocol 4 included 3 patients who underwent bilateral stellate ganglion blockade with lidocaine injection.
resultsIn patients without heart diseases, spontaneous nerve discharges were frequently observed at baseline and were associated with heart rate acceleration. SKNA recorded from chest leads (V
conclusionSKNA is detectable using conventional ECG electrodes in humans and may be useful in estimating sympathetic tone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.