Evidence map›Paper›PMID 27670593›Full record

ArticleThe Journal of experimental medicine2016

The aryl hydrocarbon receptor is required for the maintenance of liver-resident natural killer cells.

Luhua H Zhang, June Ho Shin, Mikel D Haggadone, John B Sunwoo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 85 citations in OpenAlex.

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  18. Intravital Imaging of Inflammatory Response in Liver Disease.Frontiers in cell and developmental biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Luhua H ZhangDivision of Head and Neck Surgery, Department of Otolaryngology, Program in Immunology, Stanford Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0003-3870-0574
June Ho ShinDivision of Head and Neck Surgery, Department of Otolaryngology, Program in Immunology, Stanford Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0001-9278-1331
Mikel D HaggadoneDivision of Head and Neck Surgery, Department of Otolaryngology, Program in Immunology, Stanford Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-7001-9132
John B SunwooDivision of Head and Neck Surgery, Department of Otolaryngology, Program in Immunology, Stanford Cancer Institute and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305 sunwoo@stanford.edu.ORCID 0000-0002-8393-4196
Stanford University · US

Funding

MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
Enhancement of Natural Killer Cell Effector FunctionsR01CA158516 · NCI · STANFORD UNIVERSITY · PI SUNWOO, JOHN B · 2012 to 2016
$1.7M
NCI NIH HHS R01 CA158516NIAID NIH HHS T32 AI007290
6 · The paper itself

Abstract

A tissue-resident population of natural killer cells (NK cells) in the liver has recently been described to have the unique capacity to confer immunological memory in the form of hapten-specific contact hypersensitivity independent of T and B cells. Factors regulating the development and maintenance of these liver-resident NK cells are poorly understood. The aryl hydrocarbon receptor (AhR) is a transcription factor modulated by exogenous and endogenous ligands that is important in the homeostasis of immune cells at barrier sites, such as the skin and gut. In this study, we show that liver-resident NK (NK1.1

Indexed as

AnimalsDermatitis, ContactHomeostasisIntegrin alpha1Integrin alpha2Killer Cells, NaturalLiverMice, Inbred C57BLReceptors, Aryl HydrocarbonTNF-Related Apoptosis-Inducing LigandIntegrin alpha1Integrin alpha2Receptors, Aryl HydrocarbonTNF-Related Apoptosis-Inducing Ligand

Identifiers

PMID27670593
PMCPMC5068230
OpenAlexW2525444147

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.