ArticleNature communications2016
Multi-pass microscopy.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Above-twofold quantum super-resolution microscopy enabled by multiple idler passes with entangled biphotons.Science advances · 2026Article
- Cavity-enhanced continuous-wave microscopy with potentially unstable cavity length.Scientific reports · 2025Article
- Cavity QED in a high NA resonator.Science advances · 2025Article
- Single-particle cryo-EM: alternative schemes to improve dose efficiency.Journal of synchrotron radiation · 2021Article
- Zero-trade-off multiparameter quantum estimation via simultaneously saturating multiple Heisenberg uncertainty relations.Science advances · 2021Article
- Electro-optic imaging enables efficient wide-field fluorescence lifetime microscopy.Nature communications · 2019Article
- Full-field interferometric imaging of propagating action potentials.Light, science & applications · 2018Article
- Multi-pass transmission electron microscopy.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microscopy of biological specimens often requires low light levels to avoid damage. This yields images impaired by shot noise. An improved measurement accuracy at the Heisenberg limit can be achieved exploiting quantum correlations. If sample damage is the limiting resource, an equivalent limit can be reached by passing photons through a specimen multiple times sequentially. Here we use self-imaging cavities and employ a temporal post-selection scheme to present full-field multi-pass polarization and transmission micrographs with variance reductions of 4.4±0.8 dB (11.6±0.8 dB in a lossless setup) and 4.8±0.8 dB, respectively, compared with the single-pass shot-noise limit. If the accuracy is limited by the number of detected probe particles, our measurements show a variance reduction of 25.9±0.9 dB. The contrast enhancement capabilities in imaging and in diffraction studies are demonstrated with nanostructured samples and with embryonic kidney 293T cells. This approach to Heisenberg-limited microscopy does not rely on quantum state engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.