Evidence map›Paper›PMID 27670279›Full record

ArticlePediatric surgery international2016

Blockade of the renin-angiotensin system prevents acute and immunologically relevant colitis in murine models.

Manabu Okawada, Michael W Wilson, Scott D Larsen, Elke Lipka, John Hillfinger, Daniel H Teitelbaum

Abstract read
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In one paragraph

Article in Pediatric surgery international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Renin-angiotensin system promotes colonic inflammation by inducing TAmerican journal of physiology. Gastrointestinal and liver physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Manabu OkawadaSection of Pediatric Surgery, Department of Surgery, The University of Michigan Medical School, Mott Children's Hospital, F3970, Ann Arbor, MI, 48109-0245, USA. manabu-o@juntendo.ac.jp.
Michael W WilsonDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109-1065, USA.
Scott D LarsenDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109-1065, USA.
Elke LipkaTherapeutic Systems Research Laboratories, Inc, Ann Arbor, MI, 48108, USA.
John HillfingerTherapeutic Systems Research Laboratories, Inc, Ann Arbor, MI, 48108, USA.
Daniel H TeitelbaumSection of Pediatric Surgery, Department of Surgery, The University of Michigan Medical School, Mott Children's Hospital, F3970, Ann Arbor, MI, 48109-0245, USA.
University of Michigan–Ann Arbor · USTherapeutics Systems Research Laboratories (United States) · USC. S. Mott Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBlockade of the renin-angiotensin system (RAS) has been shown to alleviate inflammatory processes in the gastrointestinal tract. The aim of this study was to determine if blockade of the RAS would be effective in an immunologically relevant colitis model, and to compare outcome with an acute colitis model.

methodsA losartan analog, CCG-203025 (C

resultsIn the DSS model, weight loss and histologic score for CCG-203025 were better than with placebo. In the IL10-/-model, ACE-I suppressed histologic damage better than CCG-203025. Both ACE-I and CCG-203025 reduced pro-inflammatory cytokines and chemokines.

conclusionsThis study demonstrated the therapeutic efficacy of both ACE-I and AT1aR-A for preventing the development of both acute and immunologically relevant colitis.

Indexed as

Acute DiseaseAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersAnimalsColitisCyclooxygenase InhibitorsDisease Models, AnimalEnalaprilatLosartanMiceMice, Inbred C57BLPiroxicamRenin-Angiotensin SystemAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersCyclooxygenase InhibitorsEnalaprilatLosartanPiroxicamAngiotensin converting enzymeAngiotensin II type Ia receptorAngiotensin II type Ia receptor antagonistColitisDextran sodium sulfateIL10

Identifiers

PMID27670279
OpenAlexW2525788315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.