Evidence map›Paper›PMID 27670072›Full record

ArticleVaccine2016

Retinaldehyde dehydrogenase 2 as a molecular adjuvant for enhancement of mucosal immunity during DNA vaccination.

Susan A Holechek, Megan S McAfee, Lizbeth M Nieves, Vanessa P Guzman, Kavita Manhas, Timothy Fouts, Kenneth Bagley, Joseph N Blattman

Open access · greenAbstract read
In one paragraph

Article in Vaccine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Susan A HolechekBiodesign Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State University, Tempe, AZ 85287-5401, United States; School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, United States; Simon A. Levin Mathematical, Computational and Modeling Sciences Center, Arizona State University, Tempe, AZ 85287-3901, United States.
Megan S McAfeeBiodesign Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State University, Tempe, AZ 85287-5401, United States; School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, United States.
Lizbeth M NievesBiodesign Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State University, Tempe, AZ 85287-5401, United States; School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, United States.
Vanessa P GuzmanBiodesign Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State University, Tempe, AZ 85287-5401, United States; School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, United States.
Kavita ManhasBiodesign Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State University, Tempe, AZ 85287-5401, United States; School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, United States.
Timothy FoutsProfectus BioSciences, Inc., Baltimore, MD 21224, United States.
Kenneth BagleyProfectus BioSciences, Inc., Baltimore, MD 21224, United States.
Joseph N BlattmanBiodesign Center for Infectious Diseases and Vaccinology, Biodesign Institute, Arizona State University, Tempe, AZ 85287-5401, United States; School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, United States. Electronic address: Joseph.Blattman@asu.edu.
Arizona State University · USProfectus Biosciences (United States) · US

Funding

Novel Mucosal Adjuvant for an HIV DNA VaccineR44AI089290 · NIAID · PROFECTUS BIOSCIENCES, INC. · PI BAGLEY, KENNETH C · 2016 to 2017
$1.5M
Novel Mucosal Adjuvant for an HIV DNA VaccineR43AI089290 · NIAID · PROFECTUS BIOSCIENCES, INC. · PI BAGLEY, KENNETH C · 2010 to 2010
$212k
NIAID NIH HHS R43 AI089290NIAID NIH HHS R44 AI089290
6 · The paper itself

Abstract

In order for vaccines to induce efficacious immune responses against mucosally transmitted pathogens, such as HIV-1, activated lymphocytes must efficiently migrate to and enter targeted mucosal sites. We have previously shown that all-trans retinoic acid (ATRA) can be used as a vaccine adjuvant to enhance mucosal CD8

Indexed as

Adjuvants, ImmunologicImmunity, MucosalAIDS VaccinesAldehyde Dehydrogenase 1 FamilyAnimalsCD8-Positive T-LymphocytesFemaleHuman Immunodeficiency Virus ProteinsImmunizationImmunologic MemoryMicePlasmidsRetinal DehydrogenaseTretinoinVaccines, DNAVacciniaAdjuvants, ImmunologicAIDS VaccinesAldehyde Dehydrogenase 1 FamilyALDH1A2 protein, humanHuman Immunodeficiency Virus ProteinsRetinal DehydrogenaseTretinoinVaccines, DNAHIV DNA vaccineMucosal protectionRALDH2 adjuvantRetinoic acid

Identifiers

PMID27670072
PMCPMC5080981
OpenAlexW2523611151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.