Evidence map›Paper›PMID 27669990›Full record

ArticleNature neuroscience2016

Evolving insights into RNA modifications and their functional diversity in the brain.

Sarah Nainar, Paul R Marshall, Christina R Tyler, Robert C Spitale, Timothy W Bredy

Abstract read
In one paragraph

Article in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. The effects of NMolecular and cellular biochemistry · 2023
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. mFrontiers in cell and developmental biology · 2022
    Article
  13. RNA Modifications and RNA Metabolism in Neurological Disease Pathogenesis.International journal of molecular sciences · 2021
    Review
  14. Article
  15. Review
  16. Article
  17. The role mMolecular brain · 2021
    Review
  18. Review
  19. Emerging Role of mFrontiers in cell and developmental biology · 2021
    Review
  20. RNA NTrends in neurosciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarah NainarDepartment of Pharmaceutical Sciences, University of California Irvine, Irvine, California, USA.
Paul R MarshallDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California, USA.
Christina R TylerDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California, USA.
Robert C SpitaleDepartment of Pharmaceutical Sciences, University of California Irvine, Irvine, California, USA.
Timothy W BredyDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California, USA.

Funding

Cracking the RNA Localization CodeDP2GM119164 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SPITALE, ROBERT C · 2015 to 2015
$2.2M
Epitranscriptomic mechanisms of fear-related learning and memoryR01MH109588 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI SPITALE, ROBERT C · 2016 to 2020
$1.9M
DNA BASE MODIFICATIONS IN NEURAL PLASTICITY AND NEUROPSYCHIATRIC DISORDERSR01MH105398 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MARCELO ANDRES · 2014 to 2016
$899k
NIGMS NIH HHS DP2 GM119164NIMH NIH HHS R01 MH105398NIMH NIH HHS R01 MH109588
6 · The paper itself

Abstract

In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeoning field of epitranscriptomics, which are predicted to be heavily involved in cognitive function. These include activity-induced RNA modifications, RNA editing, dynamic changes in the secondary structure of RNA, and RNA localization. Each is described with an emphasis on its role in regulating the function of both protein-coding genes, as well as various noncoding regulatory RNAs, and how each might influence learning and memory.

Indexed as

CognitionLearningAnimalsBrainHumansNeuronsRNARNA, UntranslatedRNARNA, Untranslated

Identifiers

PMID27669990
PMCPMC5068363

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.