Trial reportAnnals of internal medicine2016
Effect of Structured Physical Activity on Overall Burden and Transitions Between States of Major Mobility Disability in Older Persons: Secondary Analysis of a Randomized Trial.
Trial report in Annals of internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01072500 (The LIFE Study - Lifestyle Interventions and Independence for Elders), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The LIFE Study - Lifestyle Interventions and Independence for Elders
Who cites it
18 citing papers in PubMed.
- Effect of intensive blood pressure control on subtypes of mild cognitive impairment and risk of progression from SPRINT study.Journal of the American Geriatrics Society · 2022Trial
- Ratings of Perceived Exertion During Walking: Predicting Major Mobility Disability and Effect of Structured Physical Activity in Mobility-Limited Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- Fall prevention interventions in primary care to reduce fractures and falls in people aged 70 years and over: the PreFIT three-arm cluster RCT.Health technology assessment (Winchester, England) · 2021Trial
- Trial
- Participation in Physical, Cognitive, and Social Activities and the Association with Mobility Disability Transitions in Older Adults.American journal of epidemiology · 2024Article
- A qualitative exploration of community mobility experiences of wheelchair users.African journal of disability · 2024Article
- Performance of Cox regression models for composite time-to-event endpoints with component-wise censoring in randomized trials.Clinical trials (London, England) · 2023Article
- Identifying the Optimal Parameters to Express the Capacity-Activity Interrelationship of Community-Dwelling Older Adults Using Wearable Sensors.Sensors (Basel, Switzerland) · 2022Article
- Observational
- Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.Journal of the American Geriatrics Society · 2020Review
- Long-term exposure to PMEnvironmental pollution (Barking, Essex : 1987) · 2020Article
- One Hour a Week: Moving to Prevent Disability in Adults With Lower Extremity Joint Symptoms.American journal of preventive medicine · 2019Article
- Impaired Physical Performance Predicts Hospitalization Risk for Participants in the Program of All-Inclusive Care for the Elderly.Physical therapy · 2019Article
- Descriptive epidemiology of changes in objectively measured sedentary behaviour and physical activity: six-year follow-up of the EPIC-Norfolk cohort.The international journal of behavioral nutrition and physical activity · 2018Article
- Association of Physical Activity with Late-life Mobility Limitation among Women with Total Joint Replacement for Knee or Hip Osteoarthritis.The Journal of rheumatology · 2018Article
- Measuring Sarcopenia Severity in Older Adults and the Value of Effective Interventions.The journal of nutrition, health & aging · 2018Article
- Do the Tenets of Late-Life Disability Apply to Middle Age?Annals of internal medicine · 2017Article
- Growing Relevance of Cardiac Rehabilitation for an Older Population With Heart Failure.Journal of cardiac failure · 2016Review
Corrections and comments
- Commented on by
Authors and funding
13 authors.
Funding
Abstract
Background: The total time a patient is disabled likely has a greater influence on his or her quality of life than the initial occurrence of disability alone. Objective: To compare the effect of a long-term, structured physical activity program with that of a health education intervention on the proportion of patient assessments indicating major mobility disability (MMD) (that is, MMD burden) and on the risk for transitions into and out of MMD. Design: Single-blinded, parallel-group, randomized trial. (ClinicalTrials.gov: NCT01072500). Setting: 8 U.S. centers between February 2010 and December 2013. Participants: 1635 sedentary persons, aged 70 to 89 years, who had functional limitations but could walk 400 m. Intervention: Physical activity (n = 818) and health education (n = 817). Measurements: MMD, defined as the inability to walk 400 m, was assessed every 6 months for up to 3.5 years. Results: During a median follow-up of 2.7 years, the proportion of assessments showing MMD was substantially lower in the physical activity (0.13 [95% CI, 0.11 to 0.15]) than the health education (0.17 [CI, 0.15 to 0.19]) group, yielding a risk ratio of 0.75 (CI, 0.64 to 0.89). In a multistate model, the hazard ratios for comparisons of physical activity with health education were 0.87 (CI, 0.73 to 1.03) for the transition from no MMD to MMD; 0.52 (CI, 0.10 to 2.67) for no MMD to death; 1.33 (CI, 0.99 to 1.77) for MMD to no MMD; and 1.92 (CI, 1.15 to 3.20) for MMD to death. Limitation: The intention-to-treat principle was maintained for MMD burden and first transition out of no MMD, but not for subsequent transitions. Conclusion: A structured physical activity program reduced the MMD burden for an extended period, in part through enhanced recovery after the onset of disability and diminished risk for subsequent disability episodes. Primary Funding Source: National Institute on Aging, National Institutes of Health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.