ArticlePloS one2016
Femoral Bone Marrow Insulin Sensitivity Is Increased by Resistance Training in Elderly Female Offspring of Overweight and Obese Mothers.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01931540 (Developmental ORIgins of Healthy and Unhealthy AgeiNg), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developmental ORIgins of Healthy and Unhealthy AgeiNg: the Role of Maternal Obesity
Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Loading Enhances Glucose Uptake in Muscles, Bones, and Bone Marrow of Lower Extremities in Humans.The Journal of clinical endocrinology and metabolism · 2024Trial
- Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training.The Journal of clinical endocrinology and metabolism · 2020Trial
- Evaluation of bone marrow glucose uptake and adiposity in male rats after diet and exercise interventions.Frontiers in endocrinology · 2024Article
- Glucose uptake and distribution across the human skeleton using state-of-the-art total-body PET/CT.Bone research · 2023Article
- Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis.Nature communications · 2020Article
- A Partial Loss-of-Function Variant inDiabetes · 2018Article
- Molecular Interaction of Bone Marrow Adipose Tissue with Energy Metabolism.Current molecular biology reports · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow insulin sensitivity may be an important factor for bone health in addition to bone mineral density especially in insulin resistant conditions. First we aimed to study if prenatal maternal obesity plays a role in determining bone marrow insulin sensitivity in elderly female offspring. Secondly we studied if a four-month individualized resistance training intervention increases bone marrow insulin sensitivity in elderly female offspring and whether this possible positive outcome is regulated by the offspring’s mother’s obesity status. 37 frail elderly females (mean age 71.9 ± 3.1 years) of which 20 were offspring of lean/normal-weight mothers (OLM, maternal BMI ≤ 26.3 kg/m2) and 17 were offspring of obese/overweight mothers (OOM, maternal BMI ≥ 28.1 kg/m2) were studied before and after a four-month individualized resistance training intervention. Nine age- and sex-matched non-frail controls (maternal BMI ≤ 26.3 kg/m2) were studied at baseline. Femoral bone marrow (FBM) and vertebral bone marrow (VBM) insulin sensitivity were measured using [18F]fluoro-2-deoxy-D-glucose positron emission tomography with computer tomography under hyperinsulinemic euglycemic clamp. We found that bone marrow insulin sensitivity was not related to maternal obesity status but FBM insulin sensitivity correlated with whole body insulin sensitivity (R = 0.487, p = 0.001). A four-month resistance training intervention increased FBM insulin sensitivity by 47% (p = 0.006) only in OOM, while VBM insulin sensitivity remained unchanged regardless of the maternal obesity status. In conclusion, FBM and VBM glucose metabolism reacts differently to a four-month resistance training intervention in elderly women according to their maternal obesity status.
trial registrationClinicalTrials.gov NCT01931540.
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