ArticleeLife2016
A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
69 citing papers in PubMed, 109 citations in OpenAlex.
- Divergence of Melanopsin's Intrinsic Properties and Downstream Actions.bioRxiv : the preprint server for biology · 2026Article
- The Light-Eye-Brain Axis: Neurobiological Links Between Mood Disorders and Myopia-A Narrative Review.Ophthalmology and therapy · 2026Review
- PreclinicalbioRxiv : the preprint server for biology · 2026Article
- Light tunes long-term threat avoidance behavior in male mice.Nature communications · 2026Article
- Article
- A stress-sensing circuit signals to the central pacemaker to reprogram circadian rhythms.Science advances · 2025Article
- Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens.Investigative ophthalmology & visual science · 2025Article
- Developmental control of rod number via a light-dependent retrograde pathway from intrinsically photosensitive retinal ganglion cells.Developmental cell · 2024Article
- Defining spatial nonuniformities of all ipRGC types using an improved Opn4Cell reports methods · 2024Article
- A pupillary contrast response in mice and humans: Neural mechanisms and visual functions.Neuron · 2024Article
- Diversity and Molecular Evolution of Nonvisual Opsin Genes across Environmental, Developmental, and Morphological Adaptations in Frogs.Molecular biology and evolution · 2024Article
- A newbioRxiv : the preprint server for biology · 2024Article
- Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells.Nature communications · 2024Article
- Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice.Cell reports · 2024Article
- Preservation of Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) in Late Adult Mice: Implications as a Potential Biomarker for Early Onset Ocular Degenerative Diseases.Investigative ophthalmology & visual science · 2024Article
- Melanopsin-mediated optical entrainment regulates circadian rhythms in vertebrates.Communications biology · 2023Review
- The effects of ambient narrowband long-wavelength light on lens-induced myopia and form-deprivation myopia in tree shrews.Experimental eye research · 2023Article
- Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit.Science advances · 2023Article
- A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus.Nature communications · 2023Article
- Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Rapid and stable control of pupil size in response to light is critical for vision, but the neural coding mechanisms remain unclear. Here, we investigated the neural basis of pupil control by monitoring pupil size across time while manipulating each photoreceptor input or neurotransmitter output of intrinsically photosensitive retinal ganglion cells (ipRGCs), a critical relay in the control of pupil size. We show that transient and sustained pupil responses are mediated by distinct photoreceptors and neurotransmitters. Transient responses utilize input from rod photoreceptors and output by the classical neurotransmitter glutamate, but adapt within minutes. In contrast, sustained responses are dominated by non-conventional signaling mechanisms: melanopsin phototransduction in ipRGCs and output by the neuropeptide PACAP, which provide stable pupil maintenance across the day. These results highlight a temporal switch in the coding mechanisms of a neural circuit to support proper behavioral dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.