ArticleeLife2016
Recruitment of inhibition and excitation across mouse visual cortex depends on the hierarchy of interconnecting areas.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- The Logic of Thalamic Inputs onto the Molecular Taxonomy of Cortical Neurons Reveals a Visual Hierarchy.bioRxiv : the preprint server for biology · 2026Article
- Input-dependent directionality of interactions between cortical areas.bioRxiv : the preprint server for biology · 2026Article
- State-Dependent Organization of Microscale Functional Circuitry in Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- Aberrant Development of Hippocampal GABAergic Neurons Arising from Hypothyroidism Contributes to Memory Deficits in Mice Through Maf SuppressingBiomedicines · 2025Article
- Organizational Principles of the Primate Cerebral Cortex at the Single-Cell Level.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Higher-order thalamic input to cortex selectively conveys state information.Cell reports · 2025Article
- Border-ownership tuning determines the connectivity between V4 and V1 in the macaque visual system.Nature communications · 2024Article
- Multi-scale spiking network model of human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Signatures of hierarchical temporal processing in the mouse visual system.PLoS computational biology · 2024Article
- A hierarchy index for networks in the brain reveals a complex entangled organizational structure.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Organization of corticocortical and thalamocortical top-down inputs in the primary visual cortex.Nature communications · 2024Article
- A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration.Nature communications · 2024Article
- Dendrites contribute to the gradient of intrinsic timescales encompassing cortical and subcortical brain networks.Frontiers in cellular neuroscience · 2024Article
- Cortical circuitry mediating interareal touch signal amplification.Cell reports · 2023Article
- Transthalamic input to higher-order cortex selectively conveys state information.bioRxiv : the preprint server for biology · 2023Article
- Coherent mapping of position and head direction across auditory and visual cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Visual evoked feedforward-feedback traveling waves organize neural activity across the cortical hierarchy in mice.Nature communications · 2022Article
- Theory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition.Annual review of neuroscience · 2022Review
- Impact of cyclooxygenase-2 inhibition on cannabis withdrawal and circulating endocannabinoids in daily cannabis smokers.Addiction biology · 2022Article
- Anatomical and functional connectomes underlying hierarchical visual processing in mouse visual system.Brain structure & function · 2022Review
1 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Diverse features of sensory stimuli are selectively processed in distinct brain areas. The relative recruitment of inhibitory and excitatory neurons within an area controls the gain of neurons for appropriate stimulus coding. We examined how such a balance of inhibition and excitation is differentially recruited across multiple levels of a cortical hierarchy by mapping the locations and strengths of synaptic inputs to pyramidal and parvalbumin (PV)-expressing neurons in feedforward and feedback pathways interconnecting primary (V1) and two higher visual areas. While interareal excitation was stronger in PV than in pyramidal neurons in all layer 2/3 pathways, we observed a gradual scaling down of the inhibition/excitation ratio from the most feedforward to the most feedback pathway. Our results indicate that interareal gain control depends on the hierarchical position of the source and the target, the direction of information flow through the network, and the laminar location of target neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.