ArticleNano letters2016
A Nanoscale Tool for Photoacoustic-Based Measurements of Clotting Time and Therapeutic Drug Monitoring of Heparin.
Article in Nano letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 70 citations in OpenAlex.
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- Polyphenol-stabilized coacervates for enzyme-triggered drug delivery.Nature communications · 2024Article
- Red blood cell-derived materials for cancer therapy: Construction, distribution, and applications.Materials today. Bio · 2024Review
- The sound of blood: photoacoustic imaging in blood analysis.Medicine in novel technology and devices · 2023Article
- Article
- Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: "Always-On" and "Turn-On" Probes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Recent advances in aggregation-induced emission luminogens in photoacoustic imaging.European journal of nuclear medicine and molecular imaging · 2022Review
- Molecular Dynamics Approaches Dissect Molecular Mechanisms Underlying Methylene Blue-Glycosaminoglycan Interactions.Molecules (Basel, Switzerland) · 2022Article
- Design Principles Governing the Development of Theranostic Anticancer Agents and Their Nanoformulations with Photoacoustic Properties.Pharmaceutics · 2022Review
- A fiber optic photoacoustic sensor for real-time heparin monitoring.Biosensors & bioelectronics · 2022Article
- Activatable Carbocyanine Dimers for Photoacoustic and Fluorescent Detection of Protease Activity.ACS sensors · 2021Article
- Photoacoustic image-guided interventions.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Deep tissue photoacoustic imaging of nickel(II) dithiolene-containing polymeric nanoparticles in the second near-infrared window.Theranostics · 2020Article
- Listening for the therapeutic window: Advances in drug delivery utilizing photoacoustic imaging.Advanced drug delivery reviews · 2019Review
- Etiology and Measurement of Peri-Implant Crestal Bone Loss (CBL).Journal of clinical medicine · 2019Review
- Technology Advancements in Blood Coagulation Measurements for Point-of-Care Diagnostic Testing.Frontiers in bioengineering and biotechnology · 2019Review
- Strategies for Image-Guided Therapy, Surgery, and Drug Delivery Using Photoacoustic Imaging.Theranostics · 2019Review
- Silicon Carbide Nanoparticles as a Photoacoustic and Photoluminescent Dual-Imaging Contrast Agent for Long-Term Cell Tracking.Nanoscale advances · 2019Article
- A Mechanistic Investigation of Methylene Blue and Heparin Interactions and Their Photoacoustic Enhancement.Bioconjugate chemistry · 2018Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Heparin anticoagulation therapy is an indispensable feature of clinical care yet has a narrow therapeutic window and is the second most common intensive care unit (ICU) medication error. The active partial thromboplastin time (aPTT) monitors heparin but suffers from long turnaround times, a variable reference range, limited utility with low molecular weight heparin, and poor correlation to dose. Here, we describe a photoacoustic imaging technique to monitor heparin concentration using methylene blue as a simple and Federal Drug Administration-approved contrast agent. We found a strong correlation between heparin concentration and photoacoustic signal measured in phosphate buffered saline (PBS) and blood. Clinically relevant heparin concentrations were detected in blood in 32 s with a detection limit of 0.28 U/mL. We validated this imaging approach by correlation to the aPTT (Pearson's r = 0.86; p < 0.05) as well as with protamine sulfate treatment. This technique also has good utility with low molecular weight heparin (enoxaparin) including a blood detection limit of 72 μg/mL. We then used these findings to create a nanoparticle-based hybrid material that can immobilize methylene blue for potential applications as a wearable/implantable heparin sensor to maintain drug levels in the therapeutic window. To the best of our knowledge, this is the first use of photoacoustics to image anticoagulation therapy with significant potential implications to the cardiovascular and surgical community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.