Evidence map›Paper›PMID 27668844›Full record

ArticleInternational journal of cancer2017

Sorafenib with ASC-J9

Junjie Xu, Hui Lin, Gonghui Li, Yin Sun, Liang Shi, Wen-Lung Ma, Jiang Chen, Xiujun Cai, Chawnshang Chang

Open access · hybridAbstract read
In one paragraph

Article in International journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Enhanced anti-tumor therapy for hepatocellular carcinoma via sorafenib and KIAA1199-siRNA co-delivery liposomes.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. NMolecular cancer · 2020
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Junjie XuChawnshang Chang Liver Cancer Center, Departments of General Surgery and Urology, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Hui LinChawnshang Chang Liver Cancer Center, Departments of General Surgery and Urology, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Gonghui LiChawnshang Chang Liver Cancer Center, Departments of General Surgery and Urology, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Yin SunGeorge Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA.
Liang ShiChawnshang Chang Liver Cancer Center, Departments of General Surgery and Urology, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Wen-Lung MaSex Hormone Research Center, China Medical University/Hospital, Taichung, Taiwan.
Jiang ChenChawnshang Chang Liver Cancer Center, Departments of General Surgery and Urology, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Xiujun CaiChawnshang Chang Liver Cancer Center, Departments of General Surgery and Urology, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Chawnshang ChangGeorge Whipple Lab for Cancer Research, Departments of Pathology, Urology, Radiation Oncology and The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA.
Sir Run Run Shaw Hospital · CNZhejiang University · CNChina Medical University · TWChina Medical University Hospital · TWUniversity of Rochester Medical Center · USZero to Three · US

Funding

Stromal AR Roles in Prostate Hyperplasia and CancerR01CA156700 · NCI · UNIVERSITY OF ROCHESTER · PI CHANG, CHAWNSHANG, YEH, SHUYUAN · 2011 to 2015
$1.6M
NCI NIH HHS R01 CA156700
6 · The paper itself

Abstract

Sorafenib is currently used as a standard treatment to suppress the progression of hepatocellular carcinoma (HCC), especially in advanced stages. However, patients who receive Sorafenib treatment eventually develop resistance without clear mechanisms. There is a great need for better efficacy of Sorafenib treatment in combination with other therapies. Here, we demonstrated that the treatment combining Sorafenib with ASC-J9

Indexed as

AnimalsApoptosisCarcinoma, HepatocellularCell Line, TumorChemokine CCL2CurcuminDisease ProgressionDrug SynergismDrug Therapy, CombinationHumansLiver NeoplasmsMaleMiceMice, NudeNiacinamidePhenylurea CompoundsASC-J9 compoundBCL2 protein, humanCCL2 protein, humanChemokine CCL2CurcuminNiacinamidePhenylurea CompoundsProto-Oncogene Proteins c-bcl-2SorafenibSTAT3 protein, humanSTAT3 Transcription FactorASC-J9®hepatocellular carcinomaSorafenibsynergism

Identifiers

PMID27668844
PMCPMC5215679
OpenAlexW2412843427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.