ArticleJournal of acquired immune deficiency syndromes (1999)2016
Improving Depression Among HIV-Infected Adults: Transporting the Effect of a Depression Treatment Intervention to Routine Care.
Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Generalisability of an online randomised controlled trial: an empirical analysis.Journal of epidemiology and community health · 2018Trial
- Review
- When, why and how are estimated effects transported between populations? A scoping review of studies applying transportability methods.European journal of epidemiology · 2025Article
- Comparing the performance of statistical methods that generalize effect estimates from randomized controlled trials to much larger target populations.Communications in statistics: Simulation and computation · 2022Article
- Serving the Co-Morbid Mental Health and Substance Use Needs of People with HIV.Community mental health journal · 2021Article
- Viral Suppression Is Associated with HIV Treatment Self-Efficacy in a Cohort of Women in Washington, DC.AIDS patient care and STDs · 2021Article
- Trajectories of Viral Suppression in People Living With HIV Receiving Coordinated Care: Differences by Comorbidities.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Fertility Intentions and Clinical Care Attendance Among Women Living with HIV in South Africa.AIDS and behavior · 2020Article
- Depression Symptom Trajectories Among Mothers Living with HIV in Rural Uganda.AIDS and behavior · 2019Article
- Depressive Symptoms and Sexually Transmitted Disease: Evidence from a Low-Income Neighborhood of New York City.Community mental health journal · 2019Article
- Suicidality among nonadherent patients living with HIV in Buenos Aires, Argentina: prevalence and correlates.AIDS care · 2018Article
- Early, regular breast-milk pumping may lead to early breast-milk feeding cessation.Public health nutrition · 2018Article
- Measurement of depression treatment among patients receiving HIV primary care: Whither the truth?Journal of affective disorders · 2018Article
- Invited Commentary: Causal Inference Across Space and Time-Quixotic Quest, Worthy Goal, or Both?American journal of epidemiology · 2017Article
- Estimating preclinical amyloid positivity: A case study transporting ADNI to ARIC.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundDepression affects 20%-30% of people with HIV. Randomized controlled trials (RCTs) have demonstrated the effectiveness of interventions to improve depression among HIV-infected adults, but typically have highly selected populations which may limit generalizability. Inverse probability of sampling weights (IPSW) is a recently proposed method to transport (or standardize) findings from RCTs to a specific external target population.
methodsWe used IPSW to transport the 6-month effect of the Measurement-Based Care (MBC) intervention on depression from the SLAM DUNC trial to a population of HIV-infected, depressed adults in routine care in the United States between 2010 and 2014.
resultsIn the RCT, MBC was associated with an improvement in depression at 6 months of 3.6 points on the Hamilton Depression Rating scale [95% confidence interval (CI): -5.9 to -1.3]. When IPSW were used to standardize results from the trial to the target population, the intervention effect was attenuated by 1.2 points (mean improvement 2.4 points; 95% CI: -6.1 to 1.3).
conclusionsIf implemented among HIV-infected, depressed adults in routine care, MBC may be less effective than in the RCT but can still be expected to reduce depression. Attenuation of the intervention effect among adults in routine care reflects the fact that the trial enrolled a larger proportion of individuals for whom the intervention was more effective. Given the burden of depression among HIV-infected adults, more effective interventions to improve depression are urgently needed. However, examining the transportability of trial findings is essential to understand whether similar effects can be expected if interventions are scaled-up.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.