ArticleNature immunology2016
Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors.
Article in Nature immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis.The Journal of experimental medicine · 2026Article
- Unraveling CD8 lineage decisions reveals that functionally distinct CD8Nature immunology · 2026Article
- UBL3 Participates in the Early Stages of CD83-Dependent CD4European journal of immunology · 2026Article
- Single-cell transcriptome delineating asymmetric dynamics of CD4Frontiers in immunology · 2026Article
- Extracellular Matrix-Mediated Neuroendocrine Control of the Thymus.Neuroimmunomodulation · 2026Review
- PRR enhances anti-tumor immunity and suppresses colitis by promoting the development and survival of naive T and iNKT cells.Frontiers in immunology · 2025Article
- A conserved element in the first intron ofFrontiers in immunology · 2024Article
- How autoreactive thymocytes differentiate into regulatory versus effector CD4Nature immunology · 2023Article
- Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus.Nature immunology · 2022Article
- T cell self-reactivity during thymic development dictates the timing of positive selection.eLife · 2021Article
- The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus.Nature communications · 2021Article
- Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells.The Journal of allergy and clinical immunology · 2020Article
- E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex.The Journal of experimental medicine · 2019Article
- Article
- Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection.Seminars in cell & developmental biology · 2018Review
- CD69 prevents PLZFNature communications · 2018Article
- Identification of lineage-specifying cytokines that signal all CD8Nature immunology · 2017Article
- A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production.JCI insight · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Major histocompatibility complex class I (MHC I) positive selection of CD8
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.