Evidence map›Paper›PMID 27668293›Full record

ArticlePathogens & immunity2016

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?

Michael M Lederman, Paula M Cannon, Judith S Currier, Carl H June, Hans Peter Kiem, Daniel R Kuritzkes, Sharon R Lewin, David M Margolis, Joseph M McCune, John W Mellors and 5 more

Abstract read
In one paragraph

Article in Pathogens & immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Review
  2. Review
  3. HIV post-treatment controllers have distinct immunological and virological features.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Article
  5. Pre-clinic study of radiopharmaceutical for Covid-19 inactivation: Dose distribution with Monte Carlo Simulation.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2022
    Article
  6. Approach to the management of paediatric HIV spontaneous controllers.Southern African journal of infectious diseases · 2022
    Article
  7. Article
  8. Article
  9. "Our Tradition Our Enemy": A Qualitative Study of Barriers to Women's HIV Care in Jimma, Southwest Ethiopia.International journal of environmental research and public health · 2020
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Chimeric Antigen Receptor Therapy.The New England journal of medicine · 2018
    Review
  17. Review
  18. Novel Latency Reversal Agents for HIV-1 Cure.Annual review of medicine · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Michael M LedermanCase Western Reserve University School of Medicine, Cleveland, OH.
Paula M CannonUniversity of Southern California, Los Angeles, CA.
Judith S CurrierUniversity of California, Los Angeles, Los Angeles, CA.
Carl H JuneUniversity of Pennsylvania, Philadelphia, PA.
Hans Peter KiemFred Hutchinson Cancer Research Center, Seattle, WA.
Daniel R KuritzkesFred Hutchinson Cancer Research Center, Seattle, WA.
Sharon R LewinThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne and Royal Melbourne Hospital; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia.
David M MargolisUniversity of North Carolina at Chapel Hill, Chapel Hill, NC.
Joseph M McCuneUniversity of California, San Francisco, San Francisco, CA.
John W MellorsUniversity of Pittsburgh, Pittsburgh, PA.
Timothy W SchackerUniversity of Minnesota, Minneapolis, MN.
Rafick P SekalyCase Western Reserve University School of Medicine, Cleveland, OH.
Pablo TebasUniversity of Pennsylvania, Philadelphia, PA.
Bruce D WalkerHarvard University and Massachusetts Institute of Technology, Cambridge, MA.
Daniel C DouekVaccine Research Center, National Institutes of Health, Bethesda, MD.

Funding

Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Sharon L. Hillier, JONATHAN KARN · 1994 to 2026
$50.0M
Host Genomic Factors in Infectious Disease Susceptibility ZIAAI005066 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DOUEK, DANIEL CESAR · 2009 to 2025
$17.9M
The HIV ReservoirZIAAI005034 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DOUEK, DANIEL CESAR · 2009 to 2025
$7.5M
Intramural NIH HHS Z99 AI999999NIAID NIH HHS P30 AI036219NIAID NIH HHS P30 AI050410NIAID NIH HHS UM1 AI106701
6 · The paper itself

Abstract

With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding "a cure." The mere idea that cure of HIV might be possible has energized researchers and the community towards achieving this goal. Funding agencies, both governmental and private, have targeted HIV cure as a high priority; many in the field have responded to these initiatives and the cure research agenda is robust. In this "salon" two editors of

Indexed as

Berlin PatientCCR5cureelite controllereradicationfunctional cureHIVinflammationlatencyprocoagulantreservoir

Identifiers

PMID27668293
PMCPMC5033048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.