ArticleNeuroImage. Clinical
Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset.
Article in NeuroImage. Clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Structural rather than functional brain alterations that characterize the differences between major depressive disorder and primary insomnia: a comparative meta-analysis.BMC medicine · 2025Pooled it
- The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder-Fine-Grained Meta-Analyses.Depression and anxiety · 2024Pooled it
- Urinary copper is linked to regional cortical volume reductions in adolescents with major depressive disorder.Translational psychiatry · 2026Article
- Altered gray matter volume in major depressive disorder patients with psychomotor retardation.Neuroreport · 2026Article
- Prevalence and associated factors of obesity in patients with major depressive disorder at different ages of onset.European archives of psychiatry and clinical neuroscience · 2025Article
- The relationship between regional homogeneity in resting-state functional magnetic resonance imaging and cognitive function in depressive disorders with migraine.Scientific reports · 2025Article
- Neural Correlates of Early-Life Urbanization and Their Spatial Relationships with Gene Expression, Neurotransmitter, and Behavioral Domain Atlases.Molecular neurobiology · 2024Article
- Gender differences in major depressive disorder at different ages: a REST-meta-MDD project-based study.BMC psychiatry · 2024Article
- Abnormal intrinsic functional hubs and connectivity in patients with post-stroke depression.Annals of clinical and translational neurology · 2024Article
- Connectome architecture modulates the gray matter atrophy in major depression disorder patients with diverse suicidal ideations.Brain imaging and behavior · 2024Article
- Vertigo During Pregnancy: A Narrative Review of the Etiology, Pathophysiology, and Treatment.Cureus · 2024Review
- Impact of Stress on Brain Morphology: Insights into Structural Biomarkers of Stress-related Disorders.Current neuropharmacology · 2024Review
- "When You're Smiling": How Posed Facial Expressions Affect Visual Recognition of Emotions.Brain sciences · 2023Article
- Characteristics and correlation of gray matter volume and somatic symptoms in adolescent patients with depressive disorder.Frontiers in psychiatry · 2023Article
- Asthma's effect on brain connectivity and cognitive decline.Frontiers in neurology · 2022Article
- Dysmyelination by Oligodendrocyte-Specific Ablation of Ninj2 Contributes to Depressive-Like Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- A Comparative Study of Regional Homogeneity of Resting-State fMRI Between the Early-Onset and Late-Onset Recurrent Depression in Adults.Frontiers in psychology · 2022Article
- Gender differences in major depressive disorders: A resting state fMRI study.Frontiers in psychiatry · 2022Article
- Neuroplasticity and depression: Rewiring the brain's networks through pharmacological therapy (Review).Experimental and therapeutic medicine · 2021Review
- Changes in Regional Homogeneity of Medication-Free Major Depressive Disorder Patients With Different Onset Ages.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLittle is known about the pathological mechanism of early adult onset depression (EOD) and later adult onset depression (LOD). We seek to determine whether grey matter volume (GMV) change in EOD and LOD are different, which could also delineate EOD and LOD.
methodsIn present study, 147 first-episode, drug-naive patients with major depressive disorder (MDD), age between 18 and 45, were divided into two groups on the basis of age of MDD onset: the early adult onset group (age 18-29) and the later adult onset group (age 30-44), and a total of 130 gender-, and age-, matched healthy controls (HC) were also divided into two groups which fit for each patient group. Magnetic resonance imaging was conducted on all subjects. The voxel-based morphometry (VBM) approach was employed to analyze the images.
resultsWidespread abnormalities of GMV throughout parietal, temporal, limbic regions, occipital cortex and cerebellum were observed in MDD patients. Compare to young HC, reduced GMV in right fusiform gyrus, right middle temporal gyrus, vermis III and increased GMV in right middle occipital gyrus were seen in the EOD group. In contrast, relative to old HC, decreased GMV in the right hippocampus and increased GMV in the left middle temporal gyrus were observed in the LOD group. Compared to the LOD group, the EOD group had smaller GMV in right posterior cingulate cortex. There was no significant correlation between GMV of the right posterior cingulate cortex and the score of the depression rating scale in patients group.
conclusionsThe GMV of the brain areas that were related to mood regulation was decreased in the first-episode, drug-naive adult patients with MDD. Adult patients with EOD and LOD exhibited different GMV changes relative to each age-matched comparison group, suggesting depressed adult patients with different age-onset might have different pathological mechanism.
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