Evidence map›Paper›PMID 27668147›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2015

Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction.

Anwarul Hasan, Ahmad Khattab, Mohammad Ariful Islam, Khaled Abou Hweij, Joya Zeitouny, Renae Waters, Malek Sayegh, Md Monowar Hossain, Arghya Paul

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 3 pooled it
20.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 3 syntheses or guidelines pooled it, 312 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
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  6. Article
  7. Review
  8. Review
  9. Article
  10. Hydrogel-based neural engineering for skin wound healing.Frontiers in cell and developmental biology · 2026
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Targeted delivery of engineered adipose-derived stem cell secretome to promote cardiac repair after myocardial infarction.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Hydrogels for Cardiac Tissue Regeneration: Current and Future Developments.International journal of molecular sciences · 2025
    Review

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Anwarul HasanCenter for Biomedical Engineering Department of Medicine Brigham and Women's Hospital Harvard Medical School Cambridge MA 02139 USA; Harvard-MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA 02139 USA; Biomedical Engineering and Department of Mechanical Engineering Faculty of Engineering and Architecture American University of Beirut Beirut 1107 2020 Lebanon.
Ahmad KhattabDepartment of Electrical and Computer Engineering Faculty of Engineering and Architecture American University of Beirut Beirut 1107 2020 Lebanon.
Mohammad Ariful IslamLaboratory of Nanomedicine and Biomaterials Department of Anesthesiology Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA; Laboratory for Nanoengineering and Drug Delivery Brigham and Women's Hospital Harvard Medical School Boston MA 02115 USA.
Khaled Abou HweijDepartment of Mechanical Engineering Faculty of Engineering and Architecture American University of Beirut Beirut 1107 2020 Lebanon.
Joya ZeitounyDepartment of Electrical and Computer Engineering Faculty of Engineering and Architecture American University of Beirut Beirut 1107 2020 Lebanon.
Renae WatersBioIntel Research Laboratory Department of Chemical and Petroleum Engineering Bioengineering Graduate Program School of Engineering University of Kansas Lawrence KS 66045 USA.
Malek SayeghHamilton College Clinton NY 13323 USA.
Md Monowar HossainDepartment of Medicine Lyell McEwin Hospital University of Adelaide South Australia 5112 Australia.
Arghya PaulBioIntel Research Laboratory Department of Chemical and Petroleum Engineering Bioengineering Graduate Program School of Engineering University of Kansas Lawrence KS 66045 USA.
American University of Beirut · LBUniversity of Kansas · USHamilton College · USInnovation Research Center · USMassachusetts Institute of Technology · USUniversity of Adelaide · AU

Funding

Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HOLMSTROM, ERIK D · 2012 to 2021
$22.1M
NIGMS NIH HHS P20 GM103638
6 · The paper itself

Abstract

Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombosis or stenosis of devices, immune rejection, and prolonged hospitalization time. Injectable hydrogels have emerged as a promising solution for in situ cardiac tissue repair in infarcted hearts after MI. In this review, an overview of various natural and synthetic hydrogels for potential application as injectable hydrogels in cardiac tissue repair and regeneration is presented. The review starts with brief discussions about the pathology of MI, its current clinical treatments and their limitations, and the emergence of injectable hydrogels as a potential solution for post MI cardiac regeneration. It then summarizes various hydrogels, their compositions, structures and properties for potential application in post MI cardiac repair, and recent advancements in the application of injectable hydrogels in treatment of MI. Finally, the current challenges associated with the clinical application of injectable hydrogels to MI and their potential solutions are discussed to help guide the future research on injectable hydrogels for translational therapeutic applications in regeneration of cardiac tissue after MI.

Indexed as

cardiac repairhydrogelsmyocardial infarctionregenerative medicinestem celltissue engineering

Identifiers

PMID27668147
PMCPMC5033116
OpenAlexW1795880986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.