ArticleCognitive neurodynamics2016
The influence of potassium concentration on epileptic seizures in a coupled neuronal model in the hippocampus.
Article in Cognitive neurodynamics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 37 citations in OpenAlex.
- The accumulation of extracellular KScientific reports · 2025Article
- The neuronal and synaptic dynamics underlying post-inhibitory rebound burst related to major depressive disorder in the lateral habenula neuron model.Cognitive neurodynamics · 2024Article
- Examining the low-voltage fast seizure-onset and its response to optogenetic stimulation in a biophysical network model of the hippocampus.Cognitive neurodynamics · 2024Article
- Slow ion concentration oscillations and multiple states in neuron-glia interaction-insights gained from reduced mathematical models.Frontiers in network physiology · 2023Article
- Complex spiking neural networks with synaptic time-delay based on anti-interference function.Cognitive neurodynamics · 2022Article
- Adiabatic dynamic causal modelling.NeuroImage · 2021Article
- Temporal phenotyping for transitional disease progress: An application to epilepsy and Alzheimer's disease.Journal of biomedical informatics · 2020Article
- Astrocytic modulation of potassium under seizures.Neural regeneration research · 2020Review
- Dynamics of a neuron-glia system: the occurrence of seizures and the influence of electroconvulsive stimuli : A mathematical and numerical study.Journal of computational neuroscience · 2020Article
- Nucleic Acid Aptamers for Molecular Therapy of Epilepsy and Blood-Brain Barrier Damages.Molecular therapy. Nucleic acids · 2020Review
- Dynamic Transitions in Neuronal Network Firing Sustained by Abnormal Astrocyte Feedback.Neural plasticity · 2020Article
- Candidate Genes Associated with Delayed Neuropsychomotor Development and Seizures in a Patient with Ring Chromosome 20.Case reports in genetics · 2020Article
- Astrocytic Kir4.1 channels and gap junctions account for spontaneous epileptic seizure.PLoS computational biology · 2018Article
- The Energy Coding of a Structural Neural Network Based on the Hodgkin-Huxley Model.Frontiers in neuroscience · 2018Article
- Severe Convulsions and Dysmyelination in Both Jimpy and Cx32/47Neurochemical research · 2017Review
- Down-regulated expression of aquaporin-4 in the cerebellum after status epilepticus.Cognitive neurodynamics · 2017Article
- Classification of epileptic seizures using wavelet packet log energy and norm entropies with recurrent Elman neural network classifier.Cognitive neurodynamics · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Experiments on hippocampal slices have recorded that a novel pattern of epileptic seizures with alternating excitatory and inhibitory activities in the CA1 region can be induced by an elevated potassium ion (K(+)) concentration in the extracellular space between neurons and astrocytes (ECS-NA). To explore the intrinsic effects of the factors (such as glial K(+) uptake, Na(+)-K(+)-ATPase, the K(+) concentration of the bath solution, and K(+) lateral diffusion) influencing K(+) concentration in the ECS-NA on the epileptic seizures recorded in previous experiments, we present a coupled model composed of excitatory and inhibitory neurons and glia in the CA1 region. Bifurcation diagrams showing the glial K(+) uptake strength with either the Na(+)-K(+)-ATPase pump strength or the bath solution K(+) concentration are obtained for neural epileptic seizures. The K(+) lateral diffusion leads to epileptic seizure in neurons only when the synaptic conductance values of the excitatory and inhibitory neurons are within an appropriate range. Finally, we propose an energy factor to measure the metabolic demand during neuron firing, and the results show that different energy demands for the normal discharges and the pathological epileptic seizures of the coupled neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.