Evidence map›Paper›PMID 27667964›Full record

ArticleInternational journal for ion mobility spectrometry : official publication of the International Society for Ion Mobility Spectrometry2016

Gated Trapped Ion Mobility Spectrometry Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.

Mark E Ridgeway, Jeremy J Wolff, Joshua A Silveira, Cheng Lin, Catherine E Costello, Melvin A Park

Abstract read
In one paragraph

Article in International journal for ion mobility spectrometry : official publication of the International Society for Ion Mobility Spectrometry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Ion Mobility-Assisted Free Radical-Initiated Peptide Sequencing.International journal of mass spectrometry · 2025
    Article
  5. Article
  6. Review
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  11. Article
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  13. Article
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  16. Towards Discovery and Targeted Peptide Biomarker Detection Using nanoESI-TIMS-TOF MS.Journal of the American Society for Mass Spectrometry · 2018
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mark E RidgewayBruker Daltonics, 40 Manning Rd, Billerica, MA 01821.
Jeremy J WolffBruker Daltonics, 40 Manning Rd, Billerica, MA 01821.
Joshua A SilveiraBruker Daltonics, 40 Manning Rd, Billerica, MA 01821.
Cheng LinMass Spectrometry Resource, Department of Biochemistry, Boston University School of Medicine, 670 Albany Street, Suite 504, Boston, MA 02118.
Catherine E CostelloMass Spectrometry Resource, Department of Biochemistry, Boston University School of Medicine, 670 Albany Street, Suite 504, Boston, MA 02118.
Melvin A ParkBruker Daltonics, 40 Manning Rd, Billerica, MA 01821.

Funding

Mass Spectrometry Resource for Biology and MedicineP41GM104603 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2012 to 2017
$10.4M
LTQ-FT MS System for On-line Protein and Glycan AnalysisS10RR025082 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2009 to 2009
$1.3M
Characterization of glycan isomers by trapped ion mobility spectrometry-electron activated dissociation tandem mass spectrometryR21GM122635 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LIN, CHENG · 2016 to 2017
$629k
NCRR NIH HHS S10 RR025082NIGMS NIH HHS P41 GM104603NIGMS NIH HHS R21 GM122635
6 · The paper itself

Abstract

Analysis of molecules by ion mobility spectrometry coupled with mass spectrometry (IMS-MS) provides chemical information on the three dimensional structure and mass of the molecules. The coupling of ion mobility to trapping mass spectrometers has historically been challenging due to the large differences in analysis time between the two devices. In this paper we present a modification of the trapped ion mobility (TIMS) analysis scheme termed "Gated TIMS" that allows efficient coupling to a Fourier Transform Ion Cyclotron Resonance (FT-ICR) analyzer. Analyses of standard compounds and the influence of source conditions on the TIMS distributions produced by ion mobility spectra of labile ubiquitin protein ions are presented. Ion mobility resolving powers up to 100 are observed. Measured collisional cross sections of ubiquitin ions are in excellent qualitative and quantitative agreement to previous measurements. Gated TIMS FT-ICR produces results comparable to those acquired using TIMS/time-of-flight MS instrument platforms as well as numerous drift tube IMS-MS studies published in the literature.

Identifiers

PMID27667964
PMCPMC5029861

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.