ArticleAtmospheric environment (Oxford, England : 1994)2016
A bias in the "mass-normalized" DTT response - an effect of non-linear concentration-response curves for copper and manganese.
Article in Atmospheric environment (Oxford, England : 1994), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Linking Transition Metal Concentration and Oxidative Potential in PMEnvironmental science & technology · 2025Article
- Investigating the Oxidative Potential andACS ES&T air · 2025Article
- Residential Wood Burning and Vehicle Emissions as Major Sources of Environmentally Persistent Free Radicals in Fairbanks, Alaska.Environmental science & technology · 2024Article
- Inter-continental variability in the relationship of oxidative potential and cytotoxicity with PMNature communications · 2024Article
- Assessing the Oxidative Potential of Outdoor PMACS ES&T air · 2024Article
- Indoor-Outdoor Oxidative Potential of PMACS ES&T air · 2024Article
- Chemical and Cellular Formation of Reactive Oxygen Species from Secondary Organic Aerosols in Epithelial Lining Fluid.Research report (Health Effects Institute) · 2023Article
- Article
- Aerosol Oxidative Potential in the Greater Los Angeles Area: Source Apportionment and Associations with Socioeconomic Position.Environmental science & technology · 2022Article
- Seasonal and Spatial Variations of PMInternational journal of environmental research and public health · 2022Article
- Article
- Atmospheric conditions and composition that influence PMAtmospheric chemistry and physics · 2021Article
- Dithiothreitol-based oxidative potential for airborne particulate matter: an estimation of the associated uncertainty.Environmental science and pollution research international · 2020Article
- Electrochemical Dithiothreitol Assay for Large-Scale Particulate Matter Studies.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2019Article
- Personal Exposure to PMEnvironmental science & technology · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The dithiothreitol (DTT) assay is widely used to measure the oxidative potential of particulate matter. Results are typically presented in mass-normalized units (e.g., pmols DTT lost per minute per microgram PM) to allow for comparison among samples. Use of this unit assumes that the mass-normalized DTT response is constant and independent of the mass concentration of PM added to the DTT assay. However, based on previous work that identified non-linear DTT responses for copper and manganese, this basic assumption (that the mass-normalized DTT response is independent of the concentration of PM added to the assay) should not be true for samples where Cu and Mn contribute significantly to the DTT signal. To test this we measured the DTT response at multiple PM concentrations for eight ambient particulate samples collected at two locations in California. The results confirm that for samples with significant contributions from Cu and Mn, the mass-normalized DTT response can strongly depend on the concentration of PM added to the assay, varying by up to an order of magnitude for PM concentrations between 2 and 34 μg mL
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