Evidence map›Paper›PMID 27667795›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2016

Glycosylation and stem cells: Regulatory roles and application of iPSCs in the study of glycosylation-related disorders.

Ryan P Berger, Michelle Dookwah, Richard Steet, Stephen Dalton

Open access · greenAbstract readReview
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. UnravelingAnalytical chemistry · 2024
    Article
  3. Review
  4. Review
  5. Article
  6. Emerging roles of N-linked glycosylation in brain physiology and disorders.Trends in endocrinology and metabolism: TEM · 2021
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. A Rapid Array-Based Approach toJournal of proteome research · 2019
    Article
  13. Review
  14. Representing glycophenotypes: semantic unification of glycobiology resources for disease discovery.Database : the journal of biological databases and curation · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ryan P BergerDepartment of Biochemistry and Molecular Biology, Athens, GA, USA.
Michelle DookwahDepartment of Biochemistry and Molecular Biology, Athens, GA, USA.
Richard SteetDepartment of Biochemistry and Molecular Biology, Athens, GA, USA.
Stephen DaltonDepartment of Biochemistry and Molecular Biology, Athens, GA, USA.
University of Georgia · US

Funding

UNDERSTANDING MECHANISMS OF hESC SELF-RENEWAL AND CELL FATE COMMITMENTP01GM085354 · NIGMS · UNIVERSITY OF GEORGIA · PI DALTON, STEPHEN · 2008 to 2018
$18.3M
TR&D1: Stem Cell and Induced Pluripotent Stem Cell Resources (Pages 116-134)P41GM103490 · NIGMS · UNIVERSITY OF GEORGIA · PI PIERCE, J. MICHAEL · 2012 to 2018
$13.7M
New Congenital Disorders of Glycosylation: Therapy and ModelsR01DK099551 · NIDDK · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Hudson H. Freeze · 2014 to 2026
$6.7M
NIDDK NIH HHS R01 DK099551NIGMS NIH HHS P01 GM085354NIGMS NIH HHS P41 GM103490
6 · The paper itself

Abstract

Glycosylation refers to the co- and post-translational modification of protein and lipids by monosaccharides or oligosaccharide chains. The surface of mammalian cells is decorated by a heterogeneous and highly complex array of protein and lipid linked glycan structures that vary significantly between different cell types, raising questions about their roles in development and disease pathogenesis. This review will begin by focusing on recent findings that define roles for cell surface protein and lipid glycosylation in pluripotent stem cells and their functional impact during normal development. Then, we will describe how patient derived induced pluripotent stem cells are being used to model human diseases such as congenital disorders of glycosylation. Collectively, these studies indicate that cell surface glycans perform critical roles in human development and disease.

Indexed as

GlycosylationAnimalsHumansInduced Pluripotent Stem CellsLipidsMetabolism, Inborn ErrorsProteinsLipidsProteinscongenital disorders of glycosylationglycosylationpluripotent stem cells

Identifiers

PMID27667795
PMCPMC5214967
OpenAlexW2524986635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.