Evidence map›Paper›PMID 27667787›Full record

ArticleClinical and experimental immunology2017

Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4

A E Anderson, D J Swan, O Y Wong, M Buck, O Eltherington, R A Harry, A M Patterson, A G Pratt, G Reynolds, J-P Doran and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical and experimental immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Review
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  7. Article
  8. Review
  9. Review
  10. Effect of DMARDs on the immunogenicity of vaccines.Nature reviews. Rheumatology · 2023
    Review
  11. Tolerogenic dendritic cells generatedFrontiers in immunology · 2023
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. In Vitro Generation of Human Tolerogenic Monocyte-Derived Dendritic Cells.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

A E AndersonMusculoskeletal Research Group.
D J SwanMusculoskeletal Research Group.
O Y WongMusculoskeletal Research Group.
M BuckMusculoskeletal Research Group.
O EltheringtonMusculoskeletal Research Group.
R A HarryMusculoskeletal Research Group.
A M PattersonMusculoskeletal Research Group.
A G PrattMusculoskeletal Research Group.
G ReynoldsMusculoskeletal Research Group.
J-P DoranMusculoskeletal Research Group.
J A KirbyApplied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine at the Newcastle NIHR Biomedical Research Centre, Newcastle University and Newcastle upon Tyne NHS Trust, Newcastle upon Tyne, UK.
J D IsaacsMusculoskeletal Research Group.
C M U HilkensMusculoskeletal Research Group.
NIHR Oxford Musculoskeletal Biomedical Research Centre · GBVersus Arthritis · GBNIHR Newcastle Biomedical Research Centre · GBQuadram Institute · GBUniversity of Dundee · GB

Funding

Medical Research Council G1001518
6 · The paper itself

Abstract

Tolerogenic dendritic cells (tolDC) are a new immunotherapeutic tool for the treatment of rheumatoid arthritis (RA) and other autoimmune disorders. We have established a method to generate stable tolDC by pharmacological modulation of human monocyte-derived DC. These tolDC exert potent pro-tolerogenic actions on CD4

Indexed as

Immune ToleranceArthritis, RheumatoidCD4-Positive T-LymphocytesCells, CulturedCholecalciferolDendritic CellsDexamethasoneForkhead Transcription FactorsHumansImmunomodulationImmunotherapyInterleukin-12Lymphocyte ActivationSmad2 ProteinTransforming Growth Factor beta1CholecalciferolDexamethasoneForkhead Transcription FactorsFOXP3 protein, humanInterleukin-12Smad2 ProteinSMAD2 protein, humanTransforming Growth Factor beta1regulationrheumatoid arthritisTGF-β1tolerogenic dendritic cells

Identifiers

PMID27667787
PMCPMC5167049
OpenAlexW2551529727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.