ArticleObesity (Silver Spring, Md.)2016
Total and regional adiposity measured by dual-energy X-ray absorptiometry and mortality in NHANES 1999-2006.
Article in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Use of bioelectrical impedance analysis in centenarians: a systematic review.Aging clinical and experimental research · 2023Pooled it
- Body fat and risk of all-cause mortality: a systematic review and dose-response meta-analysis of prospective cohort studies.International journal of obesity (2005) · 2022Pooled it
- Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review.Frontiers in nutrition · 2021Pooled it
- Association of fat-free mass index and survival in patients with lung cancer: a multicenter cohort study.International journal of clinical oncology · 2026Article
- Fat distribution, inflammatory mechanisms, and cardiovascular disease risk: mediation analysis based on the Framingham risk score.BMC cardiovascular disorders · 2025Article
- Nutrition Focused Physical Examination Components Specific to Older Adults: A Modified Delphi Study.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Article
- Serum calcium levels and the risk of sarcopenia in young adults: insights from NHANES 2011-2018.Frontiers in nutrition · 2025Article
- Cross-validation of prediction equations for estimating the body mass index in adults without the use of body weight.PloS one · 2025Article
- Association of relative fat mass (RFM) index with diabetes-related mortality and heart disease mortality.Scientific reports · 2024Article
- Changes in body composition in early breast cancer patients treated with aromatase inhibitors.Journal of endocrinological investigation · 2024Observational
- Differential impacts of fat and muscle mass on cardiovascular and non-cardiovascular mortality in individuals with type 2 diabetes.Journal of cachexia, sarcopenia and muscle · 2024Article
- Development and cross-validation of a circumference-based predictive equation to estimate body fat in an active population.Obesity science & practice · 2024Article
- Association of daily sitting time and leisure-time physical activity with body fat among U.S. adults.Journal of sport and health science · 2024Article
- Body composition and body mass index are independently associated with widespread pain and experimental pain sensitivity in older adults: a pilot investigation.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Association of body fat distribution with all-cause and cardiovascular mortality in US adults: a secondary analysis using NHANES.BMJ open · 2023Article
- Article
- Article
- Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene.Nature communications · 2023Article
- The association between body fat distribution and bone mineral density: evidence from the US population.BMC endocrine disorders · 2022Article
- Adipokines Level and Cognitive Function-Disturbance in Homeostasis in Older People with Poorly Managed Hypertension: A Pilot Study.International journal of environmental research and public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveAssociations of overall and regional body fat measured by dual-energy X-ray absorptiometry with total and cause-specific mortality in the National Health and Nutrition Examination Survey (NHANES) 1999-2006 were investigated.
methodsThis study included 9,471 participants (≥20 years) free of major chronic diseases at baseline. Death information was obtained from the National Death Index (mean follow-up duration: 8.8 years).
resultsA total of 682 participants died after 12 months since baseline, with 206 and 170 deaths attributed to cardiovascular diseases (CVD) and cancer, respectively. The second quartile of fat mass percentages (FM%) was used as the reference to account for potential nonlinearity. In the multivariate-adjusted model, participants in the highest quartile of total FM% had increased total mortality; hazard ratio (HR; 95% confidence interval, 95% CI) was 1.48 (1.07-2.04; P < 0.05). Higher total and trunk FM%, but not leg FM%, were significantly associated with an increased CVD mortality; HRs (95% CIs) in the highest quartiles of total, trunk, and leg FM% were 2.24 (1.17-4.31), 1.93 (1.02-3.66), and 1.50 (0.77-2.94), respectively.
conclusionsHigher total body fat was associated with increased total mortality in U.S. adults. Higher total and trunk fat contents were also associated with increased CVD mortality, although fat accumulation in the lower body was not an independent predictor of mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.