ArticleStructure (London, England : 1993)2016
Common Evolutionary Origin of Procapsid Proteases, Phage Tail Tubes, and Tubes of Bacterial Type VI Secretion Systems.
Article in Structure (London, England : 1993), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
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- Origin, Evolution and Diversity of φ29-like Phages-Review and Bioinformatic Analysis.International journal of molecular sciences · 2024Review
- Phenotypic characterization and genomic analysis ofCurrent research in food science · 2024Article
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- Assembly and Capsid Expansion Mechanism of Bacteriophage P22 Revealed by High-Resolution Cryo-EM Structures.Viruses · 2023Article
- Use of an Integrated Approach Involving AlphaFold Predictions for the Evolutionary Taxonomy ofBiomolecules · 2023Article
- Structures of a large prolate virus capsid in unexpanded and expanded states generate insights into the icosahedral virus assembly.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Isolation and Characterization of a Novel Cyanophage Encoding Multiple Auxiliary Metabolic Genes.Viruses · 2022Article
- Review
- Bacteriophage ICP1: A Persistent Predator ofAnnual review of virology · 2021Article
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- Isolation, Characterization, and Genome Sequence Analysis of a Novel Lytic Phage, Xoo-sp15 Infecting Xanthomonas oryzae pv. oryzae.Current microbiology · 2021Article
- Phage gene expression and host responses lead to infection-dependent costs of CRISPR immunity.The ISME journal · 2021Article
- A Cut above the Rest: Characterization of the Assembly of a Large Viral Icosahedral Capsid.Viruses · 2020Article
- Molecular Characterization and Comparative Genomic Analysis of vB_PaeP_YA3, a Novel Temperate Bacteriophage ofFrontiers in microbiology · 2020Article
- Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships.PLoS biology · 2019Article
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- Global Proteomic Profiling ofJournal of virology · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Many large viruses, including tailed dsDNA bacteriophages and herpesviruses, assemble their capsids via formation of precursors, called procapsids or proheads. The prohead has an internal core, made of scaffolding proteins, and an outer shell, formed by the major capsid protein. The prohead usually contains a protease, which is activated during capsid maturation to destroy the inner core and liberate space for the genome. Here, we report a 2.0 Å resolution structure of the pentameric procapsid protease of bacteriophage T4, gene product (gp)21. The structure corresponds to the enzyme's pre-active state in which its N-terminal region blocks the catalytic center, demonstrating that the activation mechanism involves self-cleavage of nine N-terminal residues. We describe similarities and differences between T4 gp21 and related herpesvirus proteases. We found that gp21 and the herpesvirus proteases have similarity with proteins forming the tubes of phage tails and bacterial type VI secretion systems, suggesting their common evolutionary origin.
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