Evidence map›Paper›PMID 27667666›Full record

ArticleCell metabolism2016

Suppressors of Superoxide-H

Martin D Brand, Renata L S Goncalves, Adam L Orr, Leonardo Vargas, Akos A Gerencser, Martin Borch Jensen, Yves T Wang, Simon Melov, Carolina N Turk, Jason T Matzen and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 217 citations in OpenAlex.

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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Martin D BrandBuck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: mbrand@buckinstitute.org.
Renata L S GoncalvesBuck Institute for Research on Aging, Novato, CA 94945, USA.
Adam L OrrBuck Institute for Research on Aging, Novato, CA 94945, USA.
Leonardo VargasGenomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
Akos A GerencserBuck Institute for Research on Aging, Novato, CA 94945, USA.
Martin Borch JensenBuck Institute for Research on Aging, Novato, CA 94945, USA.
Yves T WangDepartment of Anesthesiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Simon MelovBuck Institute for Research on Aging, Novato, CA 94945, USA.
Carolina N TurkGenomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
Jason T MatzenGenomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
Victoria J DardovGenomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
H Michael PetrassiGenomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
Shelly L MeeusenGenomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
Irina V PerevoshchikovaBuck Institute for Research on Aging, Novato, CA 94945, USA.
Heinrich JasperBuck Institute for Research on Aging, Novato, CA 94945, USA.
Paul S BrookesDepartment of Anesthesiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Edward K AinscowGenomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
Buck Institute for Research on Aging · USGenomics Institute of the Novartis Research Foundation · USUniversity of Rochester Medical Center · US

Funding

The Role of the Mitochondrial UPR in Ischemic ProtectionR01HL127891 · NHLBI · UNIVERSITY OF ROCHESTER · PI BROOKES, PAUL S, NEHRKE, KEITH · 2015 to 2018
$2.5M
Redox Signaling and Stem Cell FunctionR01GM100196 · NIGMS · UNIVERSITY OF ROCHESTER · PI BOHMANN, DIRK, JASPER, HEINRICH · 2012 to 2015
$1.7M
Mitochondrial sites of reactive oxygen species generation in cells.R01AG033542 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI BRAND, MARTIN D · 2009 to 2010
$970k
Research Training and Education in GeroscienceTL1AG032116 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI GREENBERG, DAVID ALAN · 2007 to 2011
$530k
NHLBI NIH HHS R01 HL127891NIA NIH HHS R01 AG033542NIA NIH HHS TL1 AG032116NIGMS NIH HHS R01 GM100196
6 · The paper itself

Abstract

Using high-throughput screening we identified small molecules that suppress superoxide and/or H

Indexed as

CytoprotectionAnimalsAstrocytesCaspase 3Caspase 7Cell ProliferationCells, CulturedDrosophilaElectron Transport Complex IHeartHydrogen PeroxideHyperplasiaIntestinesMiceMitochondria, MuscleOxidative PhosphorylationCaspase 3Caspase 7Electron Transport Complex IHydrogen PeroxideSuperoxidesTunicamycin

Identifiers

PMID27667666
PMCPMC5061631
OpenAlexW2522162634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.