ArticleProtein science : a publication of the Protein Society2017
Crucial steps in the structure determination of a coronavirus spike glycoprotein using cryo-electron microscopy.
Article in Protein science : a publication of the Protein Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines.Nature communications · 2024Article
- Secondary Structures of MERS-CoV, SARS-CoV, and SARS-CoV-2 Spike Proteins Revealed by Infrared Vibrational Spectroscopy.International journal of molecular sciences · 2023Article
- Binding of human ACE2 and RBD of Omicron enhanced by unique interaction patterns among SARS-CoV-2 variants of concern.Journal of computational chemistry · 2023Article
- Binding of Human ACE2 and RBD of Omicron Enhanced by Unique Interaction Patterns Among SARS-CoV-2 Variants of Concern.bioRxiv : the preprint server for biology · 2022Article
- Differential Interactions between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern.Journal of chemical theory and computation · 2021Article
- Surfactants - Compounds for inactivation of SARS-CoV-2 and other enveloped viruses.Current opinion in colloid & interface science · 2021Review
- Free Energy Landscapes from SARS-CoV-2 Spike Glycoprotein Simulations Suggest that RBD Opening Can Be Modulated via Interactions in an Allosteric Pocket.Journal of the American Chemical Society · 2021Article
- Differential Interactions Between Human ACE2 and Spike RBD of SARS-CoV-2 Variants of Concern.bioRxiv : the preprint server for biology · 2021Article
- SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand?Advanced drug delivery reviews · 2021Review
- Structure and Function of Major SARS-CoV-2 and SARS-CoV Proteins.Bioinformatics and biology insights · 2021Review
- Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.Science advances · 2021Article
- Spike glycoproteins: Their significance for corona viruses and receptor binding activities for pathogenesis and viral survival.Microbial pathogenesis · 2021Review
- Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation.Nature structural & molecular biology · 2020Article
- Closing coronavirus spike glycoproteins by structure-guided design.bioRxiv : the preprint server for biology · 2020Article
- Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections.Cell reports · 2020Article
- Article
- Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike.Computational and structural biotechnology journal · 2020Article
- Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors.Nature structural & molecular biology · 2019Article
- Molecular Characteristics, Functions, and Related Pathogenicity of MERS-CoV Proteins.Engineering (Beijing, China) · 2019Review
- Structural basis for human coronavirus attachment to sialic acid receptors.Nature structural & molecular biology · 2019Article
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8 authors.
Funding
Abstract
The tremendous pandemic potential of coronaviruses was demonstrated twice in the last 15 years by two global outbreaks of deadly pneumonia. Entry of coronaviruses into cells is mediated by the transmembrane spike glycoprotein S, which forms a trimer carrying receptor-binding and membrane fusion functions. Despite their biomedical importance, coronavirus S glycoproteins have proven difficult targets for structural characterization, precluding high-resolution studies of the biologically relevant trimer. Recent technological developments in single particle cryo-electron microscopy allowed us to determine the first structure of a coronavirus S glycoprotein trimer which provided a framework to understand the mechanisms of viral entry and suggested potential inhibition strategies for this family of viruses. Here, we describe the key factors that enabled this breakthrough.
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